Withoeft Jéssica Aline, Da Costa Leonardo Silva, Marian Lucas, Baumbach Letícia Ferreira, Do Canto Olegário Juliana, Miletti Luiz Cláudio, Canal Cláudio Wageck, Casagrande Renata Assis
1 Laboratório de Patologia Animal, Centro de Ciências Agroveterinárias, Universidade do Estado de Santa Catarina - Av. Luís de Camões, 2090, Conta Dinheiro, Lages, Santa Catarina, Brazil.
3 Laboratório de Virologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Acta Vet Hung. 2022 Sep 21. doi: 10.1556/004.2022.00028.
A case of non-communicating hydrocephalus and microcephaly in a sheep fetus infected with Neospora caninum from Lages, Santa Catarina, Brazil, is reported. Macroscopically, there was moderate flattening and narrowing of the skull, and the portion of the cerebral hemispheres was markedly reduced in size, measuring 3.5 × 3.5 × 0.5 cm, with marked diffuse flattening of the brain gyri and dilation of the lateral ventricles. Cerebrospinal fluid samples were positive to N. caninum detection by PCR. Histologically, there was discrete focal lymphoplasmacytic necrotising encephalitis on the floor of the lateral ventricle, discrete multifocal gliosis and discrete multifocal lymphoplasmacytic myositis. Through the molecular detection of N. caninum in the cerebrospinal fluid, it was possible to report what appears to be the first case of non-communicating hydrocephalus and microcephaly in an ovine fetus infected with N. caninum.
据报道，在巴西圣卡塔琳娜州拉热斯一头感染犬新孢子虫的绵羊胎儿中出现了一例非交通性脑积水和小头畸形病例。宏观上，颅骨有中度扁平及变窄，大脑半球部分的尺寸明显减小，大小为3.5×3.5×0.5厘米，脑回有明显的弥漫性扁平，侧脑室扩张。脑脊液样本经聚合酶链反应检测犬新孢子虫呈阳性。组织学上，侧脑室底部有散在局灶性淋巴细胞浆细胞坏死性脑炎、散在多灶性胶质增生及散在多灶性淋巴细胞浆细胞性肌炎。通过对脑脊液中犬新孢子虫的分子检测，有可能报告了首例感染犬新孢子虫的绵羊胎儿出现非交通性脑积水和小头畸形的病例。
