Takamoto M, Harada S, Harada Y, Kitahara Y, Kawahara M, Ishibashi T, Shinoda A
Jpn J Antibiot. 1987 Apr;40(4):727-34.
We treated pneumonia due to anaerobic bacteria, Mycoplasma pneumonia, and other type of pneumonia with clindamycin-2-phosphate (CLDM-P) and studied the distribution of the drug into pleural effusion. The obtained results are summarized as follows. 1. CLDM-P showed excellent effects in all the treated cases of pneumonia due to anaerobic bacteria and Mycoplasma pneumonia. But the success rate was 50% in cases of other type of pneumonia. We suggest that the drug must be used in due consideration of the types of causative bacteria. 2. Five cases which had developed pleural effusions were treated with intravenous drip of CLDM-P 1,200 mg in 200 ml electrolytic solution to see the distribution into pleural effusions. The results showed that the distribution ratio was 9.0% on the average. Peak levels were 1.86-6.07 micrograms/ml and the concentration was as high as 1.28 micrograms/ml on the average 24 hours after administration.
我们用磷酸克林霉素（CLDM-P）治疗厌氧菌性肺炎、支原体肺炎及其他类型的肺炎，并研究了该药在胸腔积液中的分布情况。所得结果总结如下。1. CLDM-P对所有厌氧菌性肺炎和支原体肺炎治疗病例均显示出良好疗效。但其他类型肺炎病例的成功率为50%。我们建议使用该药时必须适当考虑病原菌类型。2. 对5例出现胸腔积液的患者，静脉滴注200ml电解质溶液中含1200mg的CLDM-P，以观察其在胸腔积液中的分布情况。结果显示，平均分布率为9.0%。峰值水平为1.86 - 6.07微克/毫升，给药后24小时平均浓度高达1.28微克/毫升。
