Kajiki A, Yamazaki H, Hasegawa O, Nakashima Y, Kuroiwa A, Harada S, Kido M, Iida K
Jpn J Antibiot. 1983 Dec;36(12):3456-62.
Patients with bronchopulmonary infections were treated with cefoperazone (CPZ), and the serum and pleural effusion concentrations were determined after 2g CPZ drip infusion. The following results were obtained: Eight of 10 patients treated with CPZ responded with a significant clinical improvement. Side effects were found in 4 cases; eruption in 1 case, fever and granulocytopenia in 1 case, elevation of GPT in 1 case, and thrombocytopenia in 1 case. But these side effects disappeared immediately after cessation of CPZ treatment. Intravenous drip infusion of 2 g CPZ yielded a peak serum concentration of 112.0 --210.0 micrograms/ml immediately after the end of drip infusion, and a peak pleural effusion concentration of 8.8--43.0 micrograms/ml at 2--6 hours after the end of drip infusion. The ratio of peak pleural effusion concentration to peak serum concentration was 4.4--26.9%.
支气管肺部感染患者接受头孢哌酮（CPZ）治疗，静脉滴注2g CPZ后测定血清和胸腔积液浓度。结果如下：10例接受CPZ治疗的患者中有8例临床症状显著改善。发现4例有副作用；皮疹1例，发热伴粒细胞减少1例，谷丙转氨酶升高1例，血小板减少1例。但停用CPZ治疗后这些副作用立即消失。静脉滴注2g CPZ后，滴注结束后即刻血清峰值浓度为112.0 - 210.0微克/毫升，滴注结束后2 - 6小时胸腔积液峰值浓度为8.8 - 43.0微克/毫升。胸腔积液峰值浓度与血清峰值浓度之比为4.4 - 26.9%。
