SGLT2 抑制剂在慢性肾脏病和心脏病患者中的应用：文献综述。
SGLT2 Inhibitors in Patients with Chronic Kidney Disease and Heart Disease: A Literature Review.
机构信息
Houston Methodist Hospital, Houston, Texas, US.
Weill Cornell College of Medicine, Ithaca, New York, US.
出版信息
Methodist Debakey Cardiovasc J. 2022 Sep 6;18(4):62-72. doi: 10.14797/mdcvj.1120. eCollection 2022.
Abstract
Sodium-glucose transport protein 2 inhibitors, commonly referred to as SGLT2i, are a group of prescription pharmaceuticals that are approved by the United States Food and Drug Administration for use with diet and exercise to lower blood glucose in adults with type 2 diabetes. Diabetes is a well-recognized major contributor to cardiovascular and renal disease burden. In addition to blood glucose control, SGLT2i have been shown to provide significant cardiovascular and renoprotective benefits in patients with and without diabetes. In this review, we describe current evidence related to the renal and cardiovascular benefits of using SGLT2i.
摘要
钠-葡萄糖协同转运蛋白 2 抑制剂，通常称为 SGLT2i，是一组经美国食品和药物管理局批准的处方药，可与饮食和运动一起用于降低 2 型糖尿病成人的血糖。糖尿病是公认的导致心血管和肾脏疾病负担的主要因素之一。除了控制血糖外，SGLT2i 还已被证明在有和没有糖尿病的患者中具有显著的心血管和肾脏保护作用。在这篇综述中，我们描述了与使用 SGLT2i 相关的肾脏和心血管益处的现有证据。
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