Maruyama T, Uchida K, Hara H
Jpn J Pharmacol. 1987 Apr;43(4):423-8. doi: 10.1254/jjp.43.423.
beta-Lactam antibiotics, moxalactam (LMOX), cefotaxime (CTX), flomoxef (FMOX), cefamandole (CMD), carbenicillin (CBPC) and sulbenicillin (SBPC), suppressed colony formation from human megakaryocyte progenitors (CFU-M) and granulocyte-macrophage progenitors (CFU-GM) dose-dependently. The suppressive potencies for both progenitors were weakest for CBPC and SBPC, moderate for LMOX and FMOX, and strongest for CMD and CTX. The stainability of glycoprotein IIb/IIIa complex in the megakaryocyte colonies by the monoclonal antibody was decreased by LMOX and CTX. These data suggest that beta-lactam antibiotics directly suppress proliferation of CFU-M and CFU-GM.
β-内酰胺类抗生素，拉氧头孢（LMOX）、头孢噻肟（CTX）、氟氧头孢（FMOX）、头孢孟多（CMD）、羧苄西林（CBPC）和磺苄西林（SBPC），可剂量依赖性地抑制人巨核细胞祖细胞（CFU-M）和粒细胞-巨噬细胞祖细胞（CFU-GM）的集落形成。对于这两种祖细胞，CBPC和SBPC的抑制效力最弱，LMOX和FMOX的抑制效力中等，CMD和CTX的抑制效力最强。LMOX和CTX可降低单克隆抗体对巨核细胞集落中糖蛋白IIb/IIIa复合物的染色性。这些数据表明，β-内酰胺类抗生素可直接抑制CFU-M和CFU-GM的增殖。
