Angues Raquel Valdes, Palmer Valerie S, Mazumder Rajarshi, Okot Caesar, Spencer Peter S
Oregon Health & Science University, Department of Neurology, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
David Geffen School of Medicine, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA.
eNeurologicalSci. 2022 Sep 12;29:100423. doi: 10.1016/j.ensci.2022.100423. eCollection 2022 Dec.
Nodding syndrome (NS) is a mostly East African pediatric epileptiform encephalopathy of unknown etiology that shares some clinical features with measles-associated subacute sclerosing panencephalitis (SSPE) and progressive rubella panencephalitis. Two independent studies in northern Uganda identified an association between NS and prior measles infection, while an earlier study in South Sudan found an inverse association. We report preliminary serologic analyses of antibodies to measles (MV), rubella (RV), HSV-1, and CMV viruses in northern Ugandan children with NS and Household (HC) and Community (CC) Controls. Only MV-positive titers were significantly different (3-fold and > 2-fold) in NS relative to HC and HC + CC, respectively. While these results are consistent with greater prior measles infection in Ugandan persons with NS, further studies are needed to determine whether Measles virus (MV) plays any role in the etiology and pathogenesis of NS. Resolving this issue will be invaluable for the thousands of children at risk for this devastating yet often neglected condition.
点头综合征（NS）是一种主要发生在东非的小儿癫痫样脑病，病因不明，与麻疹相关的亚急性硬化性全脑炎（SSPE）和进行性风疹全脑炎有一些共同的临床特征。乌干达北部的两项独立研究发现NS与既往麻疹感染之间存在关联，而苏丹南部的一项早期研究则发现了相反的关联。我们报告了对乌干达北部患有NS的儿童以及家庭对照（HC）和社区对照（CC）中麻疹（MV）、风疹（RV）、单纯疱疹病毒1型（HSV-1）和巨细胞病毒（CMV）病毒抗体的初步血清学分析。相对于HC和HC + CC，仅NS中的MV阳性滴度分别有显著差异（3倍和>2倍）。虽然这些结果与乌干达NS患者中既往麻疹感染率较高一致，但需要进一步研究以确定麻疹病毒（MV）是否在NS的病因和发病机制中起任何作用。解决这个问题对于成千上万面临这种毁灭性但往往被忽视疾病风险的儿童来说将是非常宝贵的。
