Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Student Research Committee, Department and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Food Funct. 2022 Oct 3;13(19):10347-10356. doi: 10.1039/d2fo00983h.
: This study aimed to evaluate the effects of decaffeinated green coffee extract (DGCE) supplementation on anthropometric indices, blood glucose, leptin, adiponectin, and neuropeptide Y (NPY) in breast cancer survivors with obesity. : A total of 44 breast cancer survivors with obesity aged between 18 and 70 years and with a mean body mass index (BMI) of 31.62 ± 4.97 kg m participated in this double-blind randomized clinical trial. Eligible patients were randomized to the intervention ( = 22) and control ( = 22) groups. They received two 400 mg capsules of DGCE or two identical placebos daily for 12 weeks. Serum concentrations of leptin, adiponectin, NPY, fasting blood sugar, insulin, and homeostatic model assessment for insulin resistance (HOMA-IR) were measured at the baseline and after completion of the intervention. Also, weight, waist circumference, fat percentage, muscle percentage, and visceral fat were measured. : There were no significant differences in terms of changes of anthropometric indices and concentrations of leptin, adiponectin, NPY, and blood sugar between the two studied groups. : Supplementation with DGCE in breast cancer survivors with obesity had no significant effect on anthropometric indices and blood glucose, leptin, adiponectin, and NPY levels.
这项研究旨在评估脱因绿咖啡提取物（DGCE）补充剂对肥胖乳腺癌幸存者的人体测量指数、血糖、瘦素、脂联素和神经肽 Y（NPY）的影响。
共有 44 名年龄在 18 至 70 岁之间、平均体重指数（BMI）为 31.62±4.97kg/m²的肥胖乳腺癌幸存者参与了这项双盲随机临床试验。符合条件的患者被随机分为干预组（n=22）和对照组（n=22）。他们每天服用两个 400mg 的 DGCE 胶囊或两个相同的安慰剂，持续 12 周。在基线和干预完成后，测量血清瘦素、脂联素、NPY、空腹血糖、胰岛素和胰岛素抵抗稳态模型评估（HOMA-IR）浓度。还测量了体重、腰围、体脂百分比、肌肉百分比和内脏脂肪。
两组之间的人体测量指数和瘦素、脂联素、NPY 和血糖浓度的变化没有显著差异。
在肥胖乳腺癌幸存者中补充 DGCE 对人体测量指数和血糖、瘦素、脂联素和 NPY 水平没有显著影响。
