远端胆管癌的外科治疗。
Surgical Treatment of Distal Cholangiocarcinoma.
机构信息
Department of Surgery, Kettering Health Dayton, Dayton, OH 45405, USA.
Departments of Oncology and Surgery, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
出版信息
Curr Oncol. 2022 Sep 17;29(9):6674-6687. doi: 10.3390/curroncol29090524.
Distal cholangiocarcinoma (dCCA) is a rare malignancy arising from the epithelial cells of the distal biliary tract and has a poor prognosis. dCCA is often clinically silent and patients commonly present with locally advanced and/or distant disease. For patients identified with early stage, resectable disease, surgical resection with negative margins remains the only curative treatment strategy available. However, despite appropriate treatment and diligent surveillance, risk of recurrence remains high with nearly 50% of patients experiencing recurrence at 5 years subsequent to surgical resection; therefore, it is prudent to continue to optimize neoadjuvant and adjuvant therapies in order to reduce the risk of recurrence and improve overall survival. In this review, we discuss the clinical presentation, workup and surgical treatment of dCCA.
远端胆管癌（dCCA）是一种罕见的恶性肿瘤，起源于远端胆道的上皮细胞，预后较差。dCCA 通常无临床症状，患者常表现为局部晚期和/或远处疾病。对于早期可切除的患者，手术切除且切缘阴性仍然是唯一可行的治愈性治疗策略。然而，尽管进行了适当的治疗和积极的监测，复发的风险仍然很高，近 50%的患者在手术后 5 年内复发；因此，谨慎地继续优化新辅助和辅助治疗以降低复发风险并改善总体生存率是明智的。在这篇综述中，我们讨论了 dCCA 的临床表现、检查和手术治疗。
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