Unit of Dental Hygiene, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Unit of Orthodontics and Pediatric Dentistry, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Oral Dis. 2023 Oct;29(7):2789-2798. doi: 10.1111/odi.14388. Epub 2022 Oct 4.
The aim of this randomized clinical trial was to evaluate the desensitizing and remineralizing effect of a new zinc-hydroxyapatite-based paste in sites affected by molar-incisor hypomineralization (MIH), by assessing dental sensitivity, tooth wear, and periodontal indexes.
Twenty-five patients with presence of 1 enamel demineralization of permanent molars and incisors in two different quadrants were recruited. After professional dental hygiene, a domiciliary hydroxyapatite-based paste was assigned and recommended to be applied on 2 MIH teeth in one random quadrant (test group), while the 2 contralateral MIH teeth did not undergo paste application (control group). The following primary outcomes were assessed: Plaque Control Record (PCR), Bleeding Index (BI), MIH Treatment Need Index (MIH-TNI), and Schiff Air Index (SAI).
No significant inter- and intragroup differences were found for PI and BI, except for both intragroup T0-T1. For MIH-TNI, significant intergroup differences were detectable in the test group after 9 months of treatment. For SAI values, no significant differences were found in the control group, while in the test group, significant lower values were found after 1 and 3 months since baseline, respectively.
Biomimetic zinc-hydroxyapatite showed a desensitizing effect when used to treat MIH.
本随机临床试验旨在通过评估脱敏和再矿化效果，来评估一种新型基于锌羟磷灰石的糊剂在受磨牙-切牙釉质不全（MIH）影响的部位的作用，同时评估牙齿敏感、牙齿磨损和牙周指数。
共招募了 25 名患者，这些患者的 2 颗恒牙和切牙有 1 处牙釉质脱矿，位于 2 个不同象限。在进行专业的口腔卫生护理后，分配了一种家庭用基于羟磷灰石的糊剂，并建议将其应用于 1 个随机象限的 2 颗 MIH 牙（实验组），而 2 颗对侧 MIH 牙不应用糊剂（对照组）。评估了以下主要结果：菌斑控制记录（PCR）、出血指数（BI）、MIH 治疗需求指数（MIH-TNI）和 Schiff 空气指数（SAI）。
PI 和 BI 无显著的组间和组内差异，但两组在 T0-T1 时均有差异。对于 MIH-TNI，实验组在治疗 9 个月后可检测到显著的组间差异。对于 SAI 值，对照组无显著差异，而实验组分别在基线后 1 个月和 3 个月时发现显著较低的值。
仿生锌羟磷灰石在治疗 MIH 时具有脱敏作用。
