Sand M E, Naftel D C, Blackstone E H, Kirklin J W, Karp R B
J Thorac Cardiovasc Surg. 1987 Aug;94(2):208-19.
A total of 101 reparative and 389 valve replacement operations, isolated or combined with tricuspid annuloplasty or operations for coronary artery disease, were done for mitral incompetence (1975 to July 1, 1983). The patients undergoing repair as a group were younger and had less hemodynamic and functional derangement than those undergoing replacement. The prevalence of repair was less (p less than 0.001) for two surgeons than for the other four, even when possible differences in patient populations were taken into account by multivariate analysis. Five-year survival rate, including hospital deaths, was 76% after valve repair and 56% after valve replacement (p = 0.005). However, by multivariate analysis, valve replacement rather than repair was only possibly (p = 0.14) a risk factor. (Multivariate analysis in all patients undergoing mitral valve repair in the period 1967 to 1985 [n = 210] did not find the type of annuloplasty to be a risk factor.) The incidence of reoperation was no different after repair or replacement and there was no increase in the risk of reoperation late after repair. Endocarditis early or late after operation occurred in 11 of the 389 patients undergoing mitral replacement and in none of those undergoing repair (p = 0.08). The functional status of the patients was not different between the two groups. These data, and the experience of others, indicate the advantages of repairing rather than replacing the incompetent mitral valve whenever possible.
1975年至1983年7月1日期间,针对二尖瓣关闭不全共进行了101例修复手术和389例瓣膜置换手术,这些手术可单独进行,也可与三尖瓣环成形术或冠状动脉疾病手术联合进行。与接受瓣膜置换的患者相比,接受修复手术的患者总体上更年轻,血流动力学和功能紊乱程度更低。即使通过多变量分析考虑了患者群体可能存在的差异,两位外科医生进行修复手术的比例仍低于其他四位外科医生(p<0.001)。包括住院死亡患者在内,瓣膜修复术后的五年生存率为76%,瓣膜置换术后为56%(p=0.005)。然而,通过多变量分析,瓣膜置换而非修复仅可能是一个危险因素(p=0.14)。(对1967年至1985年期间接受二尖瓣修复的所有患者[n=210]进行多变量分析,未发现环成形术类型是危险因素。)修复或置换术后再次手术的发生率没有差异,修复术后晚期再次手术的风险也没有增加。389例接受二尖瓣置换的患者中有11例发生了术后早期或晚期心内膜炎,而接受修复手术的患者中无一例发生(p=0.08)。两组患者的功能状态没有差异。这些数据以及其他人的经验表明,只要有可能,修复而非置换功能不全的二尖瓣具有优势。