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从美国医疗保险受益人的长期新冠特征研究中吸取的经验教训。

Lessons Learned From Characterizing Long COVID Among US Medicare Beneficiaries.

作者信息

Lu Yun, Lindaas Arnstein, Izurieta Hector S, Cozen Myrna, Menis Mikhail, Shi Xiangyu, Steele Whitney R, Wernecke Michael, Chillarige Yoganand, Kelman Jeffrey A, Forshee Richard A

机构信息

Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.

Acumen LLC, Burlingame, California, USA.

出版信息

Pharmacoepidemiol Drug Saf. 2025 Feb;34(2):e70101. doi: 10.1002/pds.70101.

Abstract

PURPOSE

To characterize long-term effects of COVID-19 among older adults (aged ≥ 65 years).

METHODS

This retrospective descriptive study utilized Medicare Fee-for-Service beneficiaries' claims to characterize post-COVID condition diagnosis code usage, long COVID (defined as post-COVID condition diagnoses made ≥ 28 days after an initial COVID-19 diagnosis) incidence, patient demographics, and concurrent diagnoses.

RESULTS

During April 1, 2020 to May 21, 2022, 193 691 (0.6%) of 31 847 927 Medicare beneficiaries were diagnosed with post-COVID conditions using ICD-10-CM diagnosis codes U09.9 and B94.8, regardless of prior COVID-19 diagnosis. Post-COVID condition diagnosis rate was higher among nursing home residents (18.7 per 1000 person-years) than community-dwelling beneficiaries (2.8). Among community-dwelling beneficiaries with a post-COVID condition diagnosis, 17.5% did not have any prior COVID-19 diagnosis code U07.1 recorded. Among beneficiaries with COVID-19 diagnosis, there were no significant sex, age, or race/ethnicity differences between those with post-COVID conditions ≥ 28 days after COVID-19 (i.e., long COVID) and those without post-COVID conditions. Certain myopathies and interstitial pulmonary disease codes were disproportionately present concurrently with long COVID compared to COVID-19.

CONCLUSIONS

In this large study of 32 million Medicare beneficiaries, we found approximately 194 000 post-COVID condition diagnoses. Post-COVID condition diagnosis rate was higher among nursing home residents, highlighting the substantial burden of COVID-19 in this vulnerable population. Community-dwelling beneficiaries were less likely to seek medical care for COVID-19 events than nursing home residents, which may suggest differences in COVID-19 severity and respiratory disease detection between these populations. Long COVID risk after COVID-19 infection may be similar across demographic groups.

摘要

目的

描述新型冠状病毒肺炎(COVID-19)对老年人(年龄≥65岁)的长期影响。

方法

这项回顾性描述性研究利用医疗保险按服务收费受益人的理赔数据,以描述COVID-19后疾病诊断代码的使用情况、长期COVID(定义为初次COVID-19诊断后≥28天进行的COVID-19后疾病诊断)的发病率、患者人口统计学特征以及并发疾病。

结果

在2020年4月1日至2022年5月21日期间,31847927名医疗保险受益人中有193691人(0.6%)使用ICD-10-CM诊断代码U09.9和B94.8被诊断为COVID-19后疾病,无论之前是否有COVID-19诊断。疗养院居民的COVID-19后疾病诊断率(每1000人年18.7例)高于社区居住受益人(每1000人年2.8例)。在有COVID-19后疾病诊断的社区居住受益人中,17.5%没有任何先前记录的COVID-19诊断代码U07.1。在患有COVID-19的受益人中,COVID-19后≥28天出现COVID-19后疾病(即长期COVID)的人与未出现COVID-19后疾病的人在性别、年龄或种族/民族方面没有显著差异。与COVID-19相比,某些肌病和间质性肺疾病代码在长期COVID患者中同时出现的比例过高。

结论

在这项对3200万医疗保险受益人的大型研究中,我们发现了约19.4万例COVID-19后疾病诊断。疗养院居民的COVID-19后疾病诊断率更高,凸显了COVID-19在这一弱势群体中的沉重负担。与疗养院居民相比,社区居住受益人因COVID-19事件寻求医疗护理的可能性较小,这可能表明这些人群在COVID-19严重程度和呼吸道疾病检测方面存在差异。COVID-19感染后长期COVID的风险在不同人口群体中可能相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ba7/11753895/a81871f0069e/PDS-34-e70101-g001.jpg

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