Lu Yun, Lindaas Arnstein, Izurieta Hector S, Cozen Myrna, Menis Mikhail, Shi Xiangyu, Steele Whitney R, Wernecke Michael, Chillarige Yoganand, Kelman Jeffrey A, Forshee Richard A
Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Acumen LLC, Burlingame, California, USA.
Pharmacoepidemiol Drug Saf. 2025 Feb;34(2):e70101. doi: 10.1002/pds.70101.
To characterize long-term effects of COVID-19 among older adults (aged ≥ 65 years).
This retrospective descriptive study utilized Medicare Fee-for-Service beneficiaries' claims to characterize post-COVID condition diagnosis code usage, long COVID (defined as post-COVID condition diagnoses made ≥ 28 days after an initial COVID-19 diagnosis) incidence, patient demographics, and concurrent diagnoses.
During April 1, 2020 to May 21, 2022, 193 691 (0.6%) of 31 847 927 Medicare beneficiaries were diagnosed with post-COVID conditions using ICD-10-CM diagnosis codes U09.9 and B94.8, regardless of prior COVID-19 diagnosis. Post-COVID condition diagnosis rate was higher among nursing home residents (18.7 per 1000 person-years) than community-dwelling beneficiaries (2.8). Among community-dwelling beneficiaries with a post-COVID condition diagnosis, 17.5% did not have any prior COVID-19 diagnosis code U07.1 recorded. Among beneficiaries with COVID-19 diagnosis, there were no significant sex, age, or race/ethnicity differences between those with post-COVID conditions ≥ 28 days after COVID-19 (i.e., long COVID) and those without post-COVID conditions. Certain myopathies and interstitial pulmonary disease codes were disproportionately present concurrently with long COVID compared to COVID-19.
In this large study of 32 million Medicare beneficiaries, we found approximately 194 000 post-COVID condition diagnoses. Post-COVID condition diagnosis rate was higher among nursing home residents, highlighting the substantial burden of COVID-19 in this vulnerable population. Community-dwelling beneficiaries were less likely to seek medical care for COVID-19 events than nursing home residents, which may suggest differences in COVID-19 severity and respiratory disease detection between these populations. Long COVID risk after COVID-19 infection may be similar across demographic groups.
描述新型冠状病毒肺炎(COVID-19)对老年人(年龄≥65岁)的长期影响。
这项回顾性描述性研究利用医疗保险按服务收费受益人的理赔数据,以描述COVID-19后疾病诊断代码的使用情况、长期COVID(定义为初次COVID-19诊断后≥28天进行的COVID-19后疾病诊断)的发病率、患者人口统计学特征以及并发疾病。
在2020年4月1日至2022年5月21日期间,31847927名医疗保险受益人中有193691人(0.6%)使用ICD-10-CM诊断代码U09.9和B94.8被诊断为COVID-19后疾病,无论之前是否有COVID-19诊断。疗养院居民的COVID-19后疾病诊断率(每1000人年18.7例)高于社区居住受益人(每1000人年2.8例)。在有COVID-19后疾病诊断的社区居住受益人中,17.5%没有任何先前记录的COVID-19诊断代码U07.1。在患有COVID-19的受益人中,COVID-19后≥28天出现COVID-19后疾病(即长期COVID)的人与未出现COVID-19后疾病的人在性别、年龄或种族/民族方面没有显著差异。与COVID-19相比,某些肌病和间质性肺疾病代码在长期COVID患者中同时出现的比例过高。
在这项对3200万医疗保险受益人的大型研究中,我们发现了约19.4万例COVID-19后疾病诊断。疗养院居民的COVID-19后疾病诊断率更高,凸显了COVID-19在这一弱势群体中的沉重负担。与疗养院居民相比,社区居住受益人因COVID-19事件寻求医疗护理的可能性较小,这可能表明这些人群在COVID-19严重程度和呼吸道疾病检测方面存在差异。COVID-19感染后长期COVID的风险在不同人口群体中可能相似。