School of Food Science and Engineering, Hainan University, Haikou 570228, China.
School of Food Science and Engineering, Hainan University, Haikou 570228, China; Key Laboratory of Food Nutrition and Functional Food of Hainan Province, Haikou 570228, China; Key Laboratory of Tropical Agricultural Products Processing Technology of Haikou, Haikou 570228, China.
Food Chem. 2023 Feb 15;402:134232. doi: 10.1016/j.foodchem.2022.134232. Epub 2022 Sep 15.
Noni fruit has certain anti-obesity effect. However, the bioactive ingredients in noni fruit that contribute to anti-obesity activity as well as the relation between its anti-obesity activity and gut microbiota remain unclear. In this study, obese mice induced by high-fat diet (HFD) and were intervened with noni fruit phenolic extract (NFE) for 10 weeks. The results showed NFE supplementation decreased body weight, lipid accumulation in liver andadiposetissues, ameliorated gut microbiota dysbiosis by increasing short-chain fatty acid (SCFA)-producing bacteria and decreasing lipopolysaccharide (LPS)-producing bacteria, and mitigated intestinal inflammation and oxidative stress. Moreover, NFE supplementation improved intestinal barrier dysfunction by elevating the protein expression levels of Claudin-1, Occludin and ZO-1, alleviated the HFD-induced intestinal inflammation by repressing the LPS/TLR4/NF-κB pathway. Collectively, the findings revealed NFE intervention inhibits obesity by improving gut microbiota disorder, barrier function, and inflammation. Hence, NFE may be an effective way to ameliorate HFD-induced damage.
诺丽果具有一定的抗肥胖作用。然而，诺丽果中具有抗肥胖活性的生物活性成分以及其抗肥胖活性与肠道微生物群之间的关系尚不清楚。在这项研究中，用高脂肪饮食（HFD）诱导肥胖小鼠，并通过给予诺丽果酚提取物（NFE）干预 10 周。结果表明，NFE 补充剂可降低体重、肝脏和脂肪组织中的脂质积累，通过增加产生短链脂肪酸（SCFA）的细菌和减少产生脂多糖（LPS）的细菌来改善肠道微生物群失调，并减轻肠道炎症和氧化应激。此外，NFE 通过提高 Claudin-1、Occludin 和 ZO-1 的蛋白表达水平来改善肠道屏障功能障碍，通过抑制 LPS/TLR4/NF-κB 通路来减轻 HFD 诱导的肠道炎症。总之，这些发现表明 NFE 通过改善肠道微生物群紊乱、屏障功能和炎症来抑制肥胖。因此，NFE 可能是改善 HFD 诱导损伤的有效方法。
