Wu Daying, Zhao Haoan, Guo Lei, Liu Xiukun, Liang Yan, Liu Qian, Cao Wei, Chen Xueyan, Gao Xin
Crop Research Institute, Shandong Academy of Agricultural Sciences/National Engineering Research Center of Wheat and Maize/National Key Laboratory of Wheat Breeding, Ministry of Science and Technology/Key Laboratory of Wheat Biology and Genetic Improvement in North Yellow & Huai River Valley, Ministry of Agriculture/Shandong Provincial Technology Innovation Center for Wheat, Jinan 250100, China.
College of Food Science and Technology, Northwest University, Xi'an 710069, China.
Foods. 2023 Dec 15;12(24):4488. doi: 10.3390/foods12244488.
Fu brick tea (FBT), a product of microbial fermentation from primary dark tea, also known as raw material tea (RMT), has been extensively studied for its functional properties. However, its potential as a staple food supplement for weight loss remains poorly understood. This study compared the weight loss effects of orlistat, traditional plain noodles (NN), and noodles supplemented with varying amounts of RMT (RMTN) and FBT (FBTN), with the aim to elucidate their lipid-reducing effects and underlying mechanisms. Experimental trials on high fat diet fed mice revealed significant weight loss, lipid-lowering, and hypoglycemic effects upon supplementation with orlistat, RMTN, and FBTN. Moreover, supplementation with orlistat, RMTN, and FBTN effectively restored serum and liver-related index levels, mitigating high-fat diet-induced dyslipidemia. Additionally, these supplements ameliorated liver and kidney damage by inhibiting oxidative stress and inflammatory responses. Furthermore, orlistat, RMTN, and FBTN exert their anti-obesity effects primarily by modulating genes associated with lipid metabolism and inflammatory responses and through regulation of the composition and structure of the gut microbiota. Importantly, FBTN demonstrated a significantly stronger lipid-lowering effect compared to RMTN, particularly at higher tea addition ratios. In contrast, NN supplementation exhibited minimal to no weight loss effects. Based on these findings, it could be inferred that FBT holds promise as a staple food supplement to ameliorate high-fat diet-induced obesity and its associated health conditions.
茯砖茶（FBT）是由初级黑茶经微生物发酵制成的产品，也被称为原料茶（RMT），其功能特性已得到广泛研究。然而，其作为减肥主食补充剂的潜力仍知之甚少。本研究比较了奥利司他、传统普通面条（NN）以及添加不同量RMT的面条（RMTN）和添加FBT的面条（FBTN）的减肥效果，旨在阐明它们的降脂作用及其潜在机制。对高脂饮食喂养小鼠的实验试验表明，补充奥利司他、RMTN和FBTN后有显著的体重减轻、降脂和降糖作用。此外，补充奥利司他、RMTN和FBTN可有效恢复血清和肝脏相关指标水平，减轻高脂饮食诱导的血脂异常。此外，这些补充剂通过抑制氧化应激和炎症反应改善肝肾损伤。此外，奥利司他、RMTN和FBTN主要通过调节与脂质代谢和炎症反应相关的基因以及通过调节肠道微生物群的组成和结构发挥其抗肥胖作用。重要的是，与RMTN相比，FBTN表现出显著更强的降脂作用，尤其是在较高的茶叶添加比例下。相比之下，补充NN的减肥效果微乎其微或没有效果。基于这些发现，可以推断FBT有望作为一种主食补充剂来改善高脂饮食诱导的肥胖及其相关健康状况。
