Bruguera M, Caballero T, Carreras E, Aymerich M, Rodés J, Rozman C
Liver. 1987 Apr;7(2):76-80. doi: 10.1111/j.1600-0676.1987.tb00320.x.
Examination of needle liver biopsy specimens from 46 patients with Hodgkin's disease revealed sinusoidal dilatation with a predominantly centrolobular and midlobular localisation in 23 cases (50%). It was present in 90% of patients with general symptoms and in only 20% of those without them (p less than 0.001), and it was unrelated to the staging, the existence of hepatic infiltration by the disease and the lymph node histology. The pathogenesis of the sinusoidal ectasia is not known, but it might be a consequence of an alteration of the sinusoidal barrier, since no abnormality of the hepatocytes or of the hepatic venules was detected at light microscopy. Sinusoidal dilatation may be considered as a further systemic manifestation of Hodgkin's disease.
对46例霍奇金病患者的肝脏穿刺活检标本进行检查发现，23例（50%）存在窦状隙扩张，主要位于小叶中心和小叶中部。在有全身症状的患者中，90%存在窦状隙扩张，而在无全身症状的患者中，只有20%存在（p<0.001），且其与分期、疾病肝脏浸润的存在以及淋巴结组织学无关。窦状隙扩张的发病机制尚不清楚，但可能是窦状隙屏障改变的结果，因为在光学显微镜下未检测到肝细胞或肝小静脉的异常。窦状隙扩张可被视为霍奇金病的另一种全身表现。
