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癌症、混沌与多细胞生物体的复杂网络模型

Cancer and Chaos and the Complex Network Model of a Multicellular Organism.

作者信息

Gecow Andrzej, Iantovics Laszlo Barna, Tez Mesut

机构信息

Independent Researcher, 999038 Warsaw, Poland.

Electrical Engineering and Information Technology, Engineering and Information Technology, George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Târgu Mureș, Romania.

出版信息

Biology (Basel). 2022 Sep 5;11(9):1317. doi: 10.3390/biology11091317.

Abstract

In the search of theoretical models describing cancer, one of promising directions is chaos. It is connected to ideas of "genome chaos" and "life on the edge of chaos", but they profoundly differ in the meaning of the term "chaos". To build any coherent models, notions used by both ideas should be firstly brought closer. The hypothesis "life on the edge of chaos" using deterministic chaos has been radically deepened developed in recent years by the discovery of half-chaos. This new view requires a deeper interpretation within the range of the cell and the organism. It has impacts on understanding "chaos" in the term "genome chaos". This study intends to present such an interpretation on the basis of which such searches will be easier and closer to intuition. We interpret genome chaos as deterministic chaos in a large module of half-chaotic network modeling the cell. We observed such chaotic modules in simulations of evolution controlled by weaker variant of natural selection. We also discuss differences between free and somatic cells in modeling their disturbance using half-chaotic networks.

摘要

在寻找描述癌症的理论模型时,一个有前景的方向是混沌。它与“基因组混沌”和“混沌边缘的生命”的概念相关,但它们在“混沌”一词的含义上有很大差异。要构建任何连贯的模型,首先应拉近这两种概念所使用的观念。近年来,通过对半混沌的发现,利用确定性混沌的“混沌边缘的生命”假说得到了根本性的深化和发展。这种新观点需要在细胞和生物体范围内进行更深入的解释。它对理解“基因组混沌”一词中的“混沌”有影响。本研究旨在给出这样一种解释,在此基础上,此类探索将更容易且更接近直觉。我们将基因组混沌解释为在模拟细胞的半混沌网络的大模块中的确定性混沌。我们在由较弱形式的自然选择控制的进化模拟中观察到了这样的混沌模块。我们还讨论了在使用半混沌网络模拟自由细胞和体细胞的扰动时它们之间的差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e540/9495805/379fab3da51f/biology-11-01317-g001.jpg

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