Taizhou People's Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou 225300, China.
Biomolecules. 2022 Sep 5;12(9):1239. doi: 10.3390/biom12091239.
Cancer is a genetic mutation disease that seriously endangers the health and life of all human beings. As one of the most amazing academic achievements in the past decade, CRISPR/Cas9 technology has been sought after by many researchers due to its powerful gene editing capability. CRISPR/Cas9 technology shows great potential in oncology, and has become one of the most promising technologies for cancer genome-editing therapeutics. However, its efficiency and the safety issues of in vivo gene editing severely limit its widespread application. Therefore, developing a suitable delivery method for the CRISPR/Cas9 system is an urgent problem to be solved at present. Rapid advances in nanomedicine suggest nanoparticles could be a viable option. In this review, we summarize the latest research on the potential use of nanoparticle-based CRISPR/Cas9 systems in cancer therapeutics, in order to further their clinical application. We hope that this review will provide a novel insight into the CRISPR/Cas9 system and offer guidance for nanocarrier designs that will enable its use in cancer clinical applications.
癌症是一种严重危害全人类健康和生命的遗传突变性疾病。CRISPR/Cas9 技术作为过去十年中最令人瞩目的学术成就之一，因其强大的基因编辑能力而受到众多研究人员的追捧。CRISPR/Cas9 技术在肿瘤学领域具有巨大的潜力，已成为癌症基因组编辑治疗最有前途的技术之一。然而，其体内基因编辑的效率和安全性问题严重限制了其广泛应用。因此，开发合适的 CRISPR/Cas9 系统的递送方法是目前亟待解决的问题。纳米医学的快速发展表明，纳米粒子可能是一种可行的选择。在这篇综述中，我们总结了基于纳米粒子的 CRISPR/Cas9 系统在癌症治疗中的潜在用途的最新研究，以期进一步将其应用于临床。我们希望这篇综述能为 CRISPR/Cas9 系统提供新的见解，并为纳米载体的设计提供指导，使其能够应用于癌症的临床治疗。
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