在伴有浆膜侵犯的结直肠癌中，[具体内容缺失]和[具体内容缺失]表达下调。
, and Are Downregulated in Colorectal Carcinoma with Serosal Invasion.
作者信息
Ranković Branislava, Boštjančič Emanuela, Zidar Nina, Žlajpah Margareta, Jeruc Jera
机构信息
Faculty of Medicine, Institute of Pathology, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.
出版信息
Biomedicines. 2022 Sep 1;10(9):2149. doi: 10.3390/biomedicines10092149.
Serosal invasion is an independent negative prognostic factor in certain cancers, including CRC. However, the mechanisms behind serosal invasion are poorly understood. We therefore assumed that epithelial-mesenchymal transition (EMT) might be involved. Our study included 34 patients with CRC, 3 stage pT2, 14 stage pT3 and 17 showing serosal invasion (stage pT4a according to TNM staging system). RNA isolated from formalin-fixed paraffin-embedded tissue samples was analysed for expression of the family and their target genes and using real-time PCR. We found upregulation of and in CRC pT3 and pT4a compared to normal mucosa, and downregulation of in CRC pT3. Moreover, we observed, downregulation of and in CRC with serosal invasion (pT4a) compared to pT3. Our results suggest the involvement of partial EMT in serosal invasion of CRC. In addition, seems to be one of the important regulators involved in serosal invasion, and in tumour growth.
浆膜侵犯是包括结直肠癌（CRC）在内的某些癌症的独立负面预后因素。然而，浆膜侵犯背后的机制尚不清楚。因此，我们推测上皮-间质转化（EMT）可能与之有关。我们的研究纳入了34例CRC患者，其中3例为pT2期，14例为pT3期，17例有浆膜侵犯（根据TNM分期系统为pT4a期）。使用实时聚合酶链反应（PCR）分析从福尔马林固定石蜡包埋组织样本中分离的RNA，以检测[相关基因家族]及其靶基因[具体基因1]和[具体基因2]的表达。我们发现，与正常黏膜相比，CRC的pT3和pT4a期[相关基因1]和[相关基因2]表达上调，而CRC的pT3期[另一基因]表达下调。此外，我们观察到，与pT3期相比，有浆膜侵犯（pT4a）的CRC中[相关基因3]和[相关基因4]表达下调。我们的结果表明，部分EMT参与了CRC的浆膜侵犯。此外，[相关基因5]似乎是参与浆膜侵犯的重要调节因子之一，而[相关基因6]参与肿瘤生长。
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