Gottlieb C F, Block N L
Med Instrum. 1987 Apr;21(2):75-80.
Hyperthermia, the intentional elevation of tissue temperature above 41 degrees C, is being intensely researched as a therapeutic modality for cancer, especially when used in combination with radiation therapy and/or chemotherapy. A serious impediment to laboratory progress in this area has been the lack of affordable equipment providing control and reproducibility when faced with highly variable factors including tumor size and shape, blood flow, heat conduction, and tissue dielectric discontinuity. Our solution has been the development of a laboratory microwave hyperthermia system, dedicated to the treatment of small, superficial tumors. This system uses a 2.45-GHz microwave generator and custom applicator to noninvasively heat a mass of tissue about 2 cm in diameter and 1.5 cm in depth. Tissue temperature at up to four locations is measured using miniature. Teflonencased thermocouples. The microwave generator and the thermometry are interfaced to a personal computer which provides fully automated hyperthermia treatment reproducible to +/- 0.2 degrees C.
热疗，即将组织温度有意升高至41摄氏度以上，作为一种癌症治疗方式正在进行深入研究，尤其是与放射治疗和/或化疗联合使用时。该领域实验室进展的一个严重障碍是缺乏价格合理的设备，在面对包括肿瘤大小和形状、血流、热传导以及组织介电不连续性等高度可变因素时，无法提供控制和再现性。我们的解决方案是开发一种实验室微波热疗系统，专门用于治疗小型浅表肿瘤。该系统使用2.45吉赫兹微波发生器和定制的施源器，以非侵入方式加热直径约2厘米、深度1.5厘米的一团组织。使用微型聚四氟乙烯包裹的热电偶测量多达四个位置的组织温度。微波发生器和温度测量装置与个人计算机相连，该计算机可提供可重复至±0.2摄氏度的全自动热疗治疗。
