白细胞中线粒体膜电位（ΔΨ）丧失作为新冠后遗症。
Loss of mitochondrial membrane potential (ΔΨ ) in leucocytes as post-COVID-19 sequelae.
机构信息
Laboratorio Nacional de Investigación para la Inocuidad Alimentaria (LANIIA)-Unidad Nayarit, Universidad Autónoma de Nayarit, Nayarit, Mexico.
Instituto Mexicano del Seguro Social (IMSS), Centro de Investigación Biomédica de Occidente (CIBO), Guadalajara, Jalisco, Mexico.
出版信息
J Leukoc Biol. 2022 Jul;112(1):23-29. doi: 10.1002/JLB.3MA0322-279RRR. Epub 2022 Mar 31.
The mitochondrial membrane potential (ΔΨ ) is a parameter often used to determine mitochondrial function; therefore, it can be used to determine the integrity and functionality of cells. A decrement of ΔΨ is implicated in several inflammatory-related pathologies, such phenomena can be related to COVID-19 infection. The present work aimed to compare the ΔΨ in leucocytes (human PBMCs; HPBMC) isolated from healthy control (HC) subjects, patients with COVID-19 (C-19), recovered subjects at 40 ± 13 (R1) and 335 ± 20 (R2) days after infection (dai). Obtained data showed that ΔΨ decreased in HPBMC of subjects with C-19, R1, and R2 compared with HC. When analyzing the ΔΨ data by sex, in females, a significant decrease was observed in R1 and R2 groups versus HC. Regarding men, a significant decrease of ΔΨ was observed in R1, with respect to HC, contrary to R2 group, who reestablished this parameter. Obtained results suggest that the loss of ΔΨ could be related to the long-COVID.
线粒体膜电位 (ΔΨ) 是常用来确定线粒体功能的参数；因此，它可用于确定细胞的完整性和功能。ΔΨ 的减少与几种与炎症相关的病理学有关，这种现象可能与 COVID-19 感染有关。本工作旨在比较来自健康对照 (HC) 受试者、COVID-19 患者 (C-19)、感染后 40 ± 13 (R1) 和 335 ± 20 (R2) 天的恢复受试者 (R2) 的白细胞 (人 PBMC；HPBMC) 中的 ΔΨ。所得数据表明，与 HC 相比，C-19、R1 和 R2 受试者的 HPBMC 中 ΔΨ 降低。当按性别分析 ΔΨ 数据时，在女性 R1 和 R2 组中观察到与 HC 相比显著降低。对于男性，与 R2 组相比，R1 组的 ΔΨ 显著降低，而 R2 组恢复了该参数。研究结果表明，ΔΨ 的丧失可能与长 COVID 有关。
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