Kovacevic Lucija, Cavka Mislav, Marusic Zlatko, Kresic Elvira, Stajduhar Andrija, Grbanovic Lora, Dumic-Cule Ivo, Prutki Maja
Clinical Department of Diagnostic and Interventional Radiology, University Hospital Center Zagreb School of Medicine, University of Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
Clinical Department of Pathology and Cytology, University Hospital Centre Zagreb, Kispaticeva 12, 10000 Zagreb, Croatia.
Diagnostics (Basel). 2022 Aug 29;12(9):2094. doi: 10.3390/diagnostics12092094.
We aimed to determine diagnostic accuracy of CT-guided bone lesion biopsy for the confirmation of bone metastases in patients with breast cancer and assessment of hormone receptor status in metastatic tissue. A total of 56 female patients with breast cancer that underwent CT-guided biopsy of suspected bone metastasis were enrolled in this retrospective study. Three different techniques were employed to obtain samples from various sites of skeleton. Collectively, 11 true negative and 3 false negative findings were revealed. The sensitivity of CT-guided biopsy for diagnosing bone metastases was 93.6%, specificity was 100% and accuracy was 94.8%. Discordance in progesterone receptor status and complete concordance in estrogen receptor status was observed. Based on our single-center experience, bone metastasis biopsy should be routinely performed in patients with breast cancer and suspicious bone lesions, due to the impact on further treatment.
我们旨在确定CT引导下骨病变活检对乳腺癌患者骨转移的确诊及转移组织中激素受体状态评估的诊断准确性。本项回顾性研究纳入了56例接受CT引导下疑似骨转移活检的女性乳腺癌患者。采用三种不同技术从骨骼的不同部位获取样本。总共发现11例假阴性和3例假阳性结果。CT引导下活检诊断骨转移瘤的灵敏度为93.6%，特异度为100%，准确度为94.8%。观察到孕激素受体状态存在不一致，而雌激素受体状态完全一致。基于我们单中心的经验，由于对进一步治疗有影响，乳腺癌合并可疑骨病变的患者应常规进行骨转移活检。
