Olteanu Vasile-Andrei, Balan Gheorghe G, Timofte Oana, Dascalu Cristina Gena, Gologan Elena, Gilca-Blanariu Georgiana-Emanuela, Diac Madalina-Maria, Sandu Ion, Stefanescu Gabriela
Gastroenterology Department, Gr. T. Popa University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania.
Institute of Gastroenterology and Hepatology, St. 1 Spiridon Emergency County Hospital, 1, Independentei Boulevard, 700111 Iasi, Romania.
Diagnostics (Basel). 2022 Sep 2;12(9):2136. doi: 10.3390/diagnostics12092136.
The assessment of fibrosis in chronic liver diseases using non-invasive methods is an important topic in hepatology. The aim of this study is to identify patients with non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis by establishing correlations between biological/ultrasound markers and non-invasively measured liver stiffness. This study enrolled 116 patients with non-alcoholic fatty liver disease, which were evaluated clinically, biologically, and by ultrasound. Liver fibrosis was quantified by measuring liver stiffness by shear wave elastography (SWE). Multiple correlation analysis of predictors of liver fibrosis identified a number of clinical, biological, and ultrasound parameters (BMI, blood glucose, albumin, platelet count, portal vein diameter, bipolar spleen diameter) that are associated with advanced liver fibrosis in patients with non-alcoholic fatty liver disease. The correlations between the degree of liver fibrosis and the risk values of some serological and ultrasound markers obtained in our study could be useful in clinical practice for the identification of advanced fibrosis in patients with NAFLD.
使用非侵入性方法评估慢性肝病中的纤维化是肝病学中的一个重要课题。本研究的目的是通过建立生物/超声标志物与非侵入性测量的肝脏硬度之间的相关性，来识别非酒精性脂肪性肝病（NAFLD）和晚期肝纤维化患者。本研究纳入了116例非酒精性脂肪性肝病患者，对其进行了临床、生物学和超声评估。通过剪切波弹性成像（SWE）测量肝脏硬度来量化肝纤维化。肝纤维化预测因素的多重相关性分析确定了一些与非酒精性脂肪性肝病患者晚期肝纤维化相关的临床、生物学和超声参数（BMI、血糖、白蛋白、血小板计数、门静脉直径、脾脏两极直径）。本研究中获得的肝纤维化程度与一些血清学和超声标志物风险值之间的相关性，可能在临床实践中有助于识别NAFLD患者的晚期纤维化。
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