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酸中毒对哺乳动物骨骼肌张力发展的影响。

Effects of acidosis on tension development in mammalian skeletal muscle.

作者信息

Ranatunga K W

出版信息

Muscle Nerve. 1987 Jun;10(5):439-45. doi: 10.1002/mus.880100510.

DOI:10.1002/mus.880100510
PMID:3614258
Abstract

Effect of carbon dioxide acidosis on the tension development in a rat skeletal muscle (extensor digitorum longus) was examined at different temperatures. Experiments were done in vitro and with direct stimulation, mostly at constant temperatures between 30-35 degrees C and 12-20 degrees C. A decrease of saline pH (8.0 to 6.5) with carbon dioxide increased the twitch and the tetanic tensions and enhanced the tension relaxation in experiments done at high temperatures. At low temperatures the same procedure decreased the tetanic tension and enhanced the tension relaxation. An increased tetanic tension at the high temperatures and a decreased tetanic tension at the low temperatures were also obtained at constant saline pH, with procedures known to decrease intracellular pH. The observations made at higher temperatures are discussed in relation to human muscle performance in exercise.

摘要

在不同温度下研究了二氧化碳酸中毒对大鼠骨骼肌(趾长伸肌)张力发展的影响。实验在体外进行并采用直接刺激,大多在30 - 35摄氏度和12 - 20摄氏度的恒定温度下进行。在高温实验中,用二氧化碳使生理盐水pH值从8.0降至6.5会增加单收缩和强直张力,并增强张力松弛。在低温下,相同操作会降低强直张力并增强张力松弛。在生理盐水pH值恒定的情况下,采用已知会降低细胞内pH值的方法,在高温时也得到了增加的强直张力,在低温时得到了降低的强直张力。结合运动中人类肌肉表现对在较高温度下的观察结果进行了讨论。

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