利用半合成叶绿素衍生物作为光敏剂的微生物光动力灭活。
Photodynamic Inactivation of Microorganisms Using Semisynthetic Chlorophyll Derivatives as Photosensitizers.
机构信息
Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, São Paulo CEP 13560-970, Brazil.
Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luís, km 235-SP-310, São Carlos, São Paulo CEP 13565-905, Brazil.
出版信息
Molecules. 2022 Sep 6;27(18):5769. doi: 10.3390/molecules27185769.
In this study, we describe the semisynthesis of cost-effective photosensitizers (PSs) derived from chlorophyll a containing different substituents and using previously described methods from the literature. We compared their structures when used in photodynamic inactivation (PDI) against , , and under different conditions. The PSs containing carboxylic acids and butyl groups were highly effective against and following our PDI protocol. Overall, our results indicate that these nature-inspired PSs are a promising alternative to selectively inactivate microorganisms using PDI.
在这项研究中，我们描述了从含有不同取代基的叶绿素 a 中通过先前文献中描述的方法半合成具有成本效益的光敏剂 (PSs)。我们比较了它们在不同条件下用于光动力失活 (PDI) 对抗,, 和 的结构。根据我们的 PDI 方案，含有羧酸和丁基的 PSs 对 和 非常有效。总的来说，我们的结果表明，这些受自然启发的 PSs 是一种有前途的替代方法，可以使用 PDI 选择性地灭活微生物。
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