Department of Biochemistry and General Chemistry, The Medical College of The University of Rzeszów, 35-959 Rzeszów, Poland.
Department of Biology and Genetics, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.
Molecules. 2022 Feb 10;27(4):1192. doi: 10.3390/molecules27041192.
Despite significant advances in early diagnosis and treatment, cancer is one of the leading causes of death. Photodynamic therapy (PDT) is a therapy for the treatment of many diseases, including cancer. This therapy uses a combination of a photosensitizer (PS), light irradiation of appropriate length and molecular oxygen. The photodynamic effect kills cancer cells through apoptosis, necrosis, or autophagy of tumor cells. PDT is a promising approach for eliminating various cancers but is not yet as widely applied in therapy as conventional chemotherapy. Currently, natural compounds with photosensitizing properties are being discovered and identified. A reduced toxicity to healthy tissues and a lower incidence of side effects inspires scientists to seek natural PS for PDT. In this review, several groups of compounds with photoactive properties are presented. The use of natural products has been shown to be a fruitful approach in the discovery of novel pharmaceuticals. This review focused on the anticancer activity of furanocoumarins, polyacetylenes, thiophenes, tolyporphins, curcumins, alkaloid and anthraquinones in relation to the light-absorbing properties. Attention will be paid to their phototoxic and anti-cancer effects on various types of cancer.
尽管在早期诊断和治疗方面取得了重大进展，但癌症仍是主要死因之一。光动力疗法（PDT）是治疗多种疾病的一种疗法，包括癌症。该疗法将光敏剂（PS）、适当波长的光照射和分子氧结合使用。光动力效应通过肿瘤细胞的凋亡、坏死或自噬杀死癌细胞。PDT 是消除各种癌症的一种很有前途的方法，但尚未像常规化疗那样广泛应用于治疗。目前，具有光敏特性的天然化合物正在被发现和鉴定。由于对健康组织的毒性降低和副作用发生率降低，激发了科学家们寻找 PDT 用天然 PS。在这篇综述中，介绍了具有光活性的几类化合物。使用天然产物在发现新型药物方面已被证明是一种富有成效的方法。本综述重点介绍呋喃香豆素、多炔、噻吩、土泊吩、姜黄素、生物碱和蒽醌类化合物与光吸收特性相关的抗癌活性。将关注它们对各种类型癌症的光毒性和抗癌作用。
