Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
PLoS One. 2024 Jan 11;19(1):e0296733. doi: 10.1371/journal.pone.0296733. eCollection 2024.
Microbiome-directed therapies are increasingly utilized to optimize thyroid function in both healthy individuals and those with thyroid disorders. However, recent doubts have been raised regarding the efficacy of probiotics, prebiotics, and synbiotics in improving thyroid function. This systematic review aimed to investigate the potential relationship between probiotics/prebiotics and thyroid function by analyzing the impact on thyroid hormone levels.
We conducted a comprehensive systematic review and meta-analysis of randomized controlled trials that investigated the effects of probiotics, prebiotics, and synbiotics on free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), and thyroid stimulating hormone receptor antibody (TRAb) levels. We searched for articles from PubMed, Scopus, Web of Science, and Embase up until April 1st, 2023, without any language restriction. Quantitative data analysis was performed using a random-effects model, with standardized mean difference (SMD) and 95% confidence interval as summary statistics. The methods and results were reported according to the PRISMA2020 statement.
A total of eight articles were included in this review. The meta-analysis showed no significant alterations in TSH (SMD: -0.01, 95% CI: -0.21, 0.20, P = 0.93; I2: 0.00%), fT4 (SMD: 0.04, 95% CI: -0.29, 0.21, P = 0.73; I2: 0.00%) or fT3 (SMD: 0.45, 95% CI: -0.14, 1.03, P = 0.43; I2: 78.00%), while a significant reduction in TRAb levels was observed (SMD: -0.85, 95% CI: -1.54, -0.15, P = 0.02; I2: 18.00%) following probiotics/prebiotics supplementation. No indication of publication bias was found.
Probiotics/prebiotics supplementation does not influence thyroid hormone levels, but may modestly reduce TRAb levels in patients with Graves' disease.
越来越多的人利用微生物组导向疗法来优化健康人群和甲状腺疾病患者的甲状腺功能。然而，最近人们对益生菌、益生元和合生菌改善甲状腺功能的功效产生了怀疑。本系统评价旨在通过分析对甲状腺激素水平的影响来研究益生菌/益生元与甲状腺功能之间的潜在关系。
我们对益生菌、益生元和合生菌对游离三碘甲状腺原氨酸（fT3）、游离甲状腺素（fT4）、促甲状腺激素（TSH）和促甲状腺激素受体抗体（TRAb）水平影响的随机对照试验进行了全面的系统评价和荟萃分析。我们从 PubMed、Scopus、Web of Science 和 Embase 搜索了截至 2023 年 4 月 1 日的文章，没有任何语言限制。使用随机效应模型进行定量数据分析，标准化均数差（SMD）和 95%置信区间作为汇总统计量。方法和结果按照 PRISMA2020 声明进行报告。
本综述共纳入 8 篇文章。荟萃分析显示 TSH（SMD：-0.01，95%CI：-0.21，0.20，P=0.93；I2：0.00%）、fT4（SMD：0.04，95%CI：-0.29，0.21，P=0.73；I2：0.00%）或 fT3（SMD：0.45，95%CI：-0.14，1.03，P=0.43；I2：78.00%）水平无显著变化，而益生菌/益生元补充后 TRAb 水平显著降低（SMD：-0.85，95%CI：-1.54，-0.15，P=0.02；I2：18.00%）。未发现发表偏倚的迹象。
益生菌/益生元补充剂不会影响甲状腺激素水平，但可能会适度降低格雷夫斯病患者的 TRAb 水平。
