Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114201, Taiwan.
Institute of Population Health Sciences, National Health Research Institutes, Miaoli 35053, Taiwan.
Nutrients. 2022 Sep 16;14(18):3825. doi: 10.3390/nu14183825.
To assess the prospective association between frailty and dietary diversity on mortality.
This prospective cohort study used the 2005-2008 Nutrition and Health Survey in Taiwan (N = 330; age ≥ 65 years) and this was linked to the Death Registry where we used the data that was recorded up to 31 January 2020. Dietary intake information was assessed using a 24-h dietary recall and food-frequency questionnaire, which were calculated a dietary diversity score (DDS; range, 0-6) and food consumption frequency. Assessment of frailty phenotypes was based on FRAIL scale which was proposed by the International Academy on Nutrition and Aging.
Frail older adults had a higher risk of all-cause mortality when they were compared to those with robust physiologies (hazard ratio [HR]: 3.73, 95% confidence interval [CI]: 2.13-6.52). Frailty and a lower DDS were associated with a higher risk of mortality (joint adjusted HR: 2.30, 95% CI: 1.11-4.75) which, compared with a robust physiology and higher DDS, were associated with a lower risk of mortality.
Frailty and a lower DDS were associated with a higher mortality. Prefrailty and frailty with a higher DDS were associated with a lower risk of mortality when compared with those with prefrailty and frailty and a lower DDS. These results suggest that eating a wide variety of foods might reduce the risk of mortality in older adults with prefrailty and frailty.
评估虚弱与饮食多样性与死亡率之间的前瞻性关联。
本前瞻性队列研究使用了台湾 2005-2008 年营养与健康调查(N=330;年龄≥65 岁),并将其与死亡登记处相关联,我们使用了截至 2020 年 1 月 31 日记录的数据。膳食摄入量信息使用 24 小时膳食回忆和食物频率问卷进行评估,计算出饮食多样性得分(DDS;范围,0-6)和食物消费频率。虚弱表型的评估基于国际营养与衰老学会提出的 FRAIL 量表。
与身体健壮的老年人相比,虚弱的老年人全因死亡率更高(危险比[HR]:3.73,95%置信区间[CI]:2.13-6.52)。虚弱和较低的 DDS 与更高的死亡率风险相关(联合调整后的 HR:2.30,95%CI:1.11-4.75),与身体健壮和较高的 DDS 相比,这与较低的死亡率风险相关。
虚弱和较低的 DDS 与较高的死亡率相关。与虚弱和较低的 DDS 相比,衰弱前期和虚弱期较高的 DDS 与较低的死亡率风险相关。这些结果表明,对于虚弱前期和虚弱的老年人,广泛摄入各种食物可能会降低死亡率风险。