Godkowicz Magdalena, Druszczyńska Magdalena
Lodz Institutes of the Polish Academy of Sciences, The Bio-Med-Chem Doctoral School, University of Lodz, 90-237 Lodz, Poland.
Department of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha12/16, 90-237 Lodz, Poland.
Vaccines (Basel). 2022 Sep 7;10(9):1487. doi: 10.3390/vaccines10091487.
The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) represent a family of cytosolic PRRs involved in the detection of intracellular pathogens such as mycobacteria or viruses. In this review, we discuss the role of NOD1, NOD2, and NLRC5 receptors in regulating antiviral and antimycobacterial immune responses by providing insight into molecular mechanisms as well as their potential health and disease implications.
先天性免疫系统通过模式识别受体（PRR）识别病原体相关分子模式，这些受体可诱导巨噬细胞中的炎性小体组装并触发信号转导通路，从而导致炎性细胞因子基因的转录。核苷酸结合寡聚化结构域（NOD）样受体（NLR）是一类胞质PRR，参与检测细胞内病原体，如分枝杆菌或病毒。在本综述中，我们通过深入了解分子机制及其对健康和疾病的潜在影响，讨论了NOD1、NOD2和NLRC5受体在调节抗病毒和抗分枝杆菌免疫反应中的作用。
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