Suppr超能文献

登革热病毒在蚊子中的垂直传播。

Vertical Transmission of Sindbis Virus in Mosquitoes.

机构信息

Department of Medical Biochemistry and Microbiology/Zoonosis Science Center, Uppsala University, Box 582, 751 23 Uppsala, Sweden.

出版信息

Viruses. 2022 Aug 30;14(9):1915. doi: 10.3390/v14091915.

Abstract

Vertical transmission (VT) is a phenomenon of vector-borne diseases where a pathogen is transferred from an infected arthropod mother to her offspring. For mosquito-borne flavi- and alphaviruses, VT is commonly viewed as rare; however, both field and experimental studies report on vertical transmission efficiency to a notably varying degree. It is likely that this reflects the different experimental methods used to test vertical transmission efficiency as well as differences between virus-vector combinations. There are very few investigations of the VT of an alphavirus in a vector. Sindbis virus (SINV) is an arthritogenic alphavirus that utilizes species as main vectors both in the summer transmission season and for its persistence over the winter period in northern latitudes. In this study, we investigated the vertical transmission of the SINV in vectors, both in the field and in experimental settings. The detection of SINV RNA in field-collected egg rafts and emerging adults shows that vertical transmission takes place in the field. Experimentally infected females gave rise to adult offspring containing SINV RNA at emergence; however, three to four weeks after emergence none of the offspring contained SINV RNA. This study shows that vertical transmission may be connected to SINV's ability to persist throughout northern winters and also highlights many aspects of viral replication that need further study.

摘要

垂直传播(VT)是一种虫媒病现象,病原体从感染的节肢动物母亲传播到她的后代。对于蚊媒黄病毒和甲病毒,VT 通常被认为很少见;然而,现场和实验研究都报告了垂直传播效率的显著差异。这很可能反映了用于测试垂直传播效率的不同实验方法以及病毒-载体组合之间的差异。很少有研究调查一种甲病毒在载体中的垂直传播。辛德毕斯病毒(SINV)是一种致关节炎的甲病毒,在夏季传播季节和北方冬季的持续时间内,主要利用 作为载体。在这项研究中,我们研究了 SINV 在 载体中的垂直传播,包括在野外和实验环境中。在野外采集的卵筏和新出现的成虫中检测到 SINV RNA 表明垂直传播发生在野外。实验感染的雌性产生了含有 SINV RNA 的成虫后代;然而,在出现后三到四周,没有一个后代含有 SINV RNA。这项研究表明,垂直传播可能与 SINV 在整个北方冬季的持续存在能力有关,同时也突出了病毒复制的许多方面,这些方面需要进一步研究。

相似文献

1
Vertical Transmission of Sindbis Virus in Mosquitoes.
Viruses. 2022 Aug 30;14(9):1915. doi: 10.3390/v14091915.
2
Sindbis Virus Infection in Non-Blood-Fed Hibernating Mosquitoes in Sweden.
Viruses. 2020 Dec 14;12(12):1441. doi: 10.3390/v12121441.
3
Experimental Infection and Transmission Competence of Sindbis Virus in Culex torrentium and Culex pipiens Mosquitoes from Northern Sweden.
Vector Borne Zoonotic Dis. 2019 Feb;19(2):128-133. doi: 10.1089/vbz.2018.2311. Epub 2018 Oct 6.
6
Vector Competence of Mosquitoes from Germany for Sindbis Virus.
Viruses. 2022 Nov 26;14(12):2644. doi: 10.3390/v14122644.
9
Detection and isolation of Sindbis virus from mosquitoes captured during an outbreak in Sweden, 2013.
Vector Borne Zoonotic Dis. 2015 Feb;15(2):133-40. doi: 10.1089/vbz.2014.1717.
10
Sindbis virus polyarthritis outbreak signalled by virus prevalence in the mosquito vectors.
PLoS Negl Trop Dis. 2019 Aug 29;13(8):e0007702. doi: 10.1371/journal.pntd.0007702. eCollection 2019 Aug.

引用本文的文献

1
A Global Systematic Review on the Potential of Metal-Based Nanoparticles in the Fight Against Mosquito Vectors.
J Trop Med. 2025 Jun 9;2025:2420073. doi: 10.1155/jotm/2420073. eCollection 2025.
2
West Nile Virus (WNV): One-Health and Eco-Health Global Risks.
Vet Sci. 2025 Mar 19;12(3):288. doi: 10.3390/vetsci12030288.
3
Significance of vertical transmission of arboviruses in mosquito-borne disease epidemiology.
Parasit Vectors. 2025 Apr 9;18(1):137. doi: 10.1186/s13071-025-06761-8.
6
Towards modelling tick-virus interactions using the weakly pathogenic virus: Evidence that ticks are competent vectors.
Front Cell Infect Microbiol. 2024 Mar 19;14:1334351. doi: 10.3389/fcimb.2024.1334351. eCollection 2024.
7
Medically Significant Vector-Borne Viral Diseases in Iran.
Microorganisms. 2023 Dec 18;11(12):3006. doi: 10.3390/microorganisms11123006.
8
Mosquito-borne viruses causing human disease in Fennoscandia-Past, current, and future perspectives.
Front Med (Lausanne). 2023 Mar 27;10:1152070. doi: 10.3389/fmed.2023.1152070. eCollection 2023.
9
Culex Y Virus: A Native Virus of Culex Species Characterized In Vivo.
Viruses. 2023 Jan 14;15(1):235. doi: 10.3390/v15010235.

本文引用的文献

3
Sindbis Virus Infection in Non-Blood-Fed Hibernating Mosquitoes in Sweden.
Viruses. 2020 Dec 14;12(12):1441. doi: 10.3390/v12121441.
4
Evidence of transovarial transmission of Chikungunya and Dengue viruses in field-caught mosquitoes in Kenya.
PLoS Negl Trop Dis. 2020 Jun 19;14(6):e0008362. doi: 10.1371/journal.pntd.0008362. eCollection 2020 Jun.
5
Vertical Transmission of Zika Virus in Produces Potentially Infectious Progeny.
Am J Trop Med Hyg. 2020 Aug;103(2):876-883. doi: 10.4269/ajtmh.19-0698. Epub 2020 Jun 4.
6
Overwintering of West Nile Virus in the United States.
J Med Entomol. 2019 Oct 28;56(6):1498-1507. doi: 10.1093/jme/tjz070.
7
Sindbis virus polyarthritis outbreak signalled by virus prevalence in the mosquito vectors.
PLoS Negl Trop Dis. 2019 Aug 29;13(8):e0007702. doi: 10.1371/journal.pntd.0007702. eCollection 2019 Aug.
8
Introduction and Dispersal of Sindbis Virus from Central Africa to Europe.
J Virol. 2019 Jul 30;93(16). doi: 10.1128/JVI.00620-19. Print 2019 Aug 15.
9
Insect-pathogen interactions: contribution of viral adaptation to the emergence of vector-borne diseases, the example of chikungunya.
Curr Opin Insect Sci. 2015 Aug;10:14-21. doi: 10.1016/j.cois.2015.04.010. Epub 2015 Apr 23.
10
West Nile virus in overwintering mosquitoes, central Europe.
Parasit Vectors. 2017 Oct 2;10(1):452. doi: 10.1186/s13071-017-2399-7.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验