2年后接受胃旁路手术患者的肝脏标志物和血脂谱分析——队列回顾性研究。
Analysis of hepatic markers and lipid profile of patients submitted to gastric by-pass after 2 years - Cohort retrospective.
作者信息
Pedron Flaviana Freitas, de Moura Deise Silva, Calcing Aline, Patias Luciana Dapieve, Alvarez Glauco da Costa, de Assunção Machado Ana Cristina, de Moraes Cristina Machado Bragança
机构信息
Universidade Franciscana - UFN, Brazil.
Pontifícia Universidade Católica do Rio Grande do Sul - PUCRS, Brazil.
出版信息
Ann Med Surg (Lond). 2022 Aug 5;81:104211. doi: 10.1016/j.amsu.2022.104211. eCollection 2022 Sep.
OBJETIVE
To assess the impact of %PEP on liver indicators and lipid profile two years after BS.
BACKGROUND
The prevalence of weight gain in the adult population continues to increase, 57.8% of the world's adult population will be overweight or obese by 2030.
METHODS
This is a retrospective cohort and descriptive study, performed by consulting the database of an Obesity and Digestive Surgery Clinic in the city of Santa Maria - (Rio Grande do Sul, Brazil). The study included 351 patients (284 women, 67 men), aged at least 18 years, who underwent bariatric surgery from March 2014 to March 2016. The following data were obtained from the patients' medical records: Weight, height, age, sex, associated morbidities, biochemical parameters. The data were described by mean and standard deviation, median and interquartile range, count, and percentages.
RESULTS
The results showed a significant reduction in excess loss, triglycerides (TG) and low-density lipoprotein (LDLc) cholesterol variables in the prospective period, while high-density lipoprotein (HDLc) cholesterol levels increased, thus minimizing the hepatic changes. There was a reduction in LDLc and an increase in HDLc at 24 months in both groups 1 and 2. Between 6 and 12 months, total cholesterol (TC) increased in group 2, however, in the period between 12 and 18 months, only G1 had triglycerides reduced. In the period of 18 and 24 months, there was a significant reduction in blood glucose in group 1. The variables AST and ALT were within the normal range, without significance. However, 84.3% of patients had grade I hepatic steatosis.
CONCLUSION
Bariatric surgery is effective in reducing the %EWL, modifying the lipid profile and liver markers up to 24 months after the bypass, reducing associated comorbidities. More research is needed to clarify the impact of %PEP on liver indicators and lipid profile two years after SB.
目的
评估胃旁路手术后两年，%PEP 对肝脏指标和血脂谱的影响。
背景
成年人群体重增加的患病率持续上升，到 2030 年，全球 57.8%的成年人口将超重或肥胖。
方法
这是一项回顾性队列研究和描述性研究，通过查阅圣玛丽亚市（巴西南里奥格兰德州）一家肥胖与消化外科诊所的数据库进行。该研究纳入了 351 例患者（284 名女性，67 名男性），年龄至少 18 岁，他们在 2014 年 3 月至 2016 年 3 月期间接受了减肥手术。从患者病历中获取了以下数据：体重、身高、年龄、性别、相关合并症、生化参数。数据用均值和标准差、中位数和四分位间距、计数及百分比进行描述。
结果
结果显示，在前瞻期，超重减轻、甘油三酯（TG）和低密度脂蛋白（LDLc）胆固醇变量显著降低，而高密度脂蛋白（HDLc）胆固醇水平升高，从而使肝脏变化最小化。第 1 组和第 2 组在 24 个月时 LDLc 降低，HDLc 升高。在 6 至 12 个月期间，第 2 组总胆固醇（TC）升高，然而，在 12 至 18 个月期间，只有第 1 组甘油三酯降低。在 18 至 24 个月期间，第 1 组血糖显著降低。谷草转氨酶（AST）和谷丙转氨酶（ALT）变量在正常范围内，无显著性差异。然而，84.3%的患者有 I 级肝脂肪变性。
结论
减肥手术在胃旁路术后 24 个月内有效降低%EWL、改善血脂谱和肝脏指标，减少相关合并症。需要更多研究来阐明胃旁路术后两年%PEP 对肝脏指标和血脂谱的影响。
Zotero 插件