中枢注射精氨酸加压素（AVP）可促进大鼠的社会记忆。

Centrally injected arginine vasopressin (AVP) facilitates social memory in rats.

作者信息

Le Moal M, Dantzer R, Michaud B, Koob G F

出版信息

Neurosci Lett. 1987 Jun 26;77(3):353-9. doi: 10.1016/0304-3940(87)90527-1.

Abstract

'Memory' for a juvenile conspecific in male rats can be measured by variation in duration of investigation times when the same juvenile is presented at different intervals. Typically, exposure of an adult male rat to a juvenile results in transient investigatory activity that rapidly declines with repeated exposures at short interexposure intervals (30 min). Longer interexposure intervals (120 min) result in re-investigation with durations similar or greater than the original investigation. Arginine vasopressin (AVP) injected into adult male rats intracerebroventricularly in doses of 0.5-2.0 ng immediately after investigation of the juvenile decreased social investigation of the same juvenile at the long (120 min) interexposure interval. This decrease in investigatory time was similar to that observed after a 30-min interexposure interval in untreated animals. These results support the hypothesis that increasing the availability of AVP in the central nervous system can improve the consolidation of olfactory information and improve conspecific recognition in rats.

摘要

当以不同间隔呈现同一只幼年大鼠时，雄性大鼠对幼年同种个体的“记忆”可通过探究时间的持续变化来衡量。通常，成年雄性大鼠接触幼鼠会导致短暂的探究活动，在短的暴露间隔（30分钟）下重复暴露时，这种活动会迅速下降。较长的暴露间隔（120分钟）会导致再次探究，其持续时间与最初的探究相似或更长。在对幼鼠进行探究后，立即以0.5 - 2.0纳克的剂量脑室内注射精氨酸加压素（AVP）到成年雄性大鼠体内，会减少在长（120分钟）暴露间隔时对同一只幼鼠的社交探究。这种探究时间的减少与未处理动物在30分钟暴露间隔后观察到的情况相似。这些结果支持了这样的假设，即增加中枢神经系统中AVP的可用性可以改善嗅觉信息的巩固，并提高大鼠对同种个体的识别能力。