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一名年轻女性因脑海绵状血管畸形导致蛛网膜下腔出血

Subarachnoid Hemorrhage due to Cerebral Cavernous Malformation in a Young Female.

作者信息

Thurman Cleopatra, Qureshi Kasim, Deol Baljit, Farooq Muhammad U

机构信息

Mercy Health Grand Rapids Vascular Neurology Fellowship, Grand Rapids, MI, USA.

Mercy Health Hauenstein Neuroscience Center, Grand Rapids, MI, USA.

出版信息

Neurohospitalist. 2022 Oct;12(4):669-671. doi: 10.1177/19418744221112133. Epub 2022 Jun 30.

DOI:10.1177/19418744221112133
PMID:36147757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9485698/
Abstract

Cerebral cavernous malformations (CCMs) are usually intraparenchymal lesions commonly associated with intraparenchymal hemorrhage. Extra-axial Lesions are uncommon and have rarely been reported as the cause of aneurysmal like subarachnoid hemorrhage (SAH). We present a 33-years-old female with a past medical history significant for hypertension who presented with acute onset head and neck pain after bending over. En route to the hospital, she had abnormal motor movements suggestive of seizures. Computed tomography (CT) of the head was significant for diffuse aneurysmal like SAH. Head CT angiography (CTA) and catheter digital subtraction angiography (DSA) were both negative for aneurysm. Magnetic resonance imaging (MRI) of the brain showed susceptibility artifact in the right parafalcine frontal lobe suspicious for underlying CCM. This lesion was in the area suspected of having an aneurysm on CT head. The patient was diagnosed with SAH secondary to cavernous malformation mimicking aneurysmal etiology. This case is important as it serves as a good reminder to consider cavernous malformations in the differential in patients presenting with angiogram negative SAH. Diagnosis of this entity has treatment implications including discontinuation of calcium channel blockers if initiated, discussion about duration of anti-seizure medication, in addition to consideration for surgical intervention in select populations.

摘要

脑海绵状血管畸形(CCMs)通常是脑实质内病变,常与脑实质内出血相关。轴外病变并不常见,很少被报道为动脉瘤样蛛网膜下腔出血(SAH)的病因。我们报告一名33岁女性,有高血压病史,弯腰后出现急性发作的头部和颈部疼痛。在送往医院途中,她出现提示癫痫发作的异常运动。头部计算机断层扫描(CT)显示弥漫性动脉瘤样SAH。头部CT血管造影(CTA)和导管数字减影血管造影(DSA)均未发现动脉瘤。脑部磁共振成像(MRI)显示右侧大脑镰旁额叶有磁敏感伪影,怀疑有潜在的CCM。该病变位于头部CT上怀疑有动脉瘤的区域。患者被诊断为继发于海绵状血管畸形的SAH,病因类似动脉瘤。该病例很重要,因为它很好地提醒我们,对于血管造影阴性的SAH患者,在鉴别诊断时要考虑海绵状血管畸形。该疾病的诊断对治疗有影响,包括如果已开始使用钙通道阻滞剂则停药、讨论抗癫痫药物的使用时长,此外还要考虑对特定人群进行手术干预。

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本文引用的文献

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Cavernous angioma presenting with subarachnoid hemorrhage which was diffusely distributed in the basal cisterns and mimicked intracranial aneurysm rupture.海绵状血管瘤伴蛛网膜下腔出血,出血弥漫分布于脑基底池,类似颅内动脉瘤破裂。
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