甲状腺功能正常对甲状腺功能亢进症相关性肺动脉高压患者肺动脉收缩压的影响——一项系统评价

Impact of achieving euthyroidism on pulmonary artery systolic pressures in hyperthyroidism-associated pulmonary hypertension - a systematic review.

作者信息

Chacko Shireen R, Ram Pradhum, Fox Tamaryn, Sooknanan Naveen, Lo Kevin Bryan, Menezes Ritesh G, Lasrado Savita, Eiger Glenn, Vaidya Anjali

机构信息

Department of Medicine, Albert Einstein Medical Center Philadelphia PA, United States of America.

Division of Cardiology, Emory University Hospital Atlanta, GA, United States of America.

出版信息

Am J Cardiovasc Dis. 2022 Aug 15;12(4):212-223. eCollection 2022.

DOI:

PMID:36147789

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9490158/

Abstract

In this systematic review, we seek to clarify the impact of treatment of hyperthyroidism on pulmonary hypertension in patients with both these conditions. We included 39 of 709 articles retrieved, that studied patients with hyperthyroidism and pulmonary hypertension (PH). From these, those with a documented pre-treatment Pulmonary Artery Systolic Pressure (PASP) > 35 mmHg and complete follow up were analyzed, yielding 3 case series and 22 case reports with a total of 81 cases. A significant improvement in PASP was noted with achieving euthyroidism in the 3 case series. The case reports showed a significant reduction in mean PASP from 60.5 ± 13.2 mmHg to 37.5 ± 10.1 mmHg (p < 0.001) in patients with Grave's disease with achieving euthyroidism. No deaths were reported during the follow up period. Achievement of a euthyroid state in patients with hyperthyroidism is associated with statistically significant reductions in PASP.

摘要

在这项系统评价中，我们试图阐明甲状腺功能亢进症的治疗对同时患有这两种疾病的患者的肺动脉高压的影响。我们从检索到的709篇文章中纳入了39篇，这些文章研究了甲状腺功能亢进症和肺动脉高压（PH）患者。从中分析那些记录的治疗前肺动脉收缩压（PASP）>35 mmHg且有完整随访资料的患者，得到3个病例系列和22篇病例报告，共81例。在3个病例系列中，随着甲状腺功能恢复正常，PASP有显著改善。病例报告显示，Graves病患者在甲状腺功能恢复正常后，平均PASP从60.5±13.2 mmHg显著降至37.5±10.1 mmHg（p<0.001）。随访期间未报告死亡病例。甲状腺功能亢进症患者甲状腺功能恢复正常与PASP的统计学显著降低相关。