Cellcure Center, Gatot Soebroto Central Army Hospital, Jakarta, Indonesia.
Front Immunol. 2022 Sep 6;13:989685. doi: 10.3389/fimmu.2022.989685. eCollection 2022.
Finding a vaccine that can last a long time and effective against viruses with high mutation rates such as SARS-CoV-2 is still a challenge today. The various vaccines that have been available have decreased in effectiveness and require booster administration. As the professional antigen presenting cell, Dendritic Cells can also activate the immune system, especially T cells. This ability makes dendritic cells have been developed as vaccines for some types of diseases. In SARS-CoV-2 infection, T cells play a vital role in eliminating the virus, and their presence can be detected in the long term. Hence, this condition shows that the formation of T cell immunity is essential to prevent and control the course of the disease. The construction of vaccines oriented to induce strong T cells response can be formed by utilizing dendritic cells. In this article, we discuss and illustrate the role of dendritic cells and T cells in the pathogenesis of SARS-CoV-2 infection and summarizing the crucial role of dendritic cells in the formation of T cell immunity. We arrange the basis concept of developing dendritic cells for SARS-CoV-2 vaccines. A dendritic cell-based vaccine for SARS-CoV-2 has the potential to be an effective vaccine that solves existing problems.
寻找一种能够长时间有效对抗高突变率病毒（如 SARS-CoV-2）的疫苗仍然是当今的一个挑战。现有的各种疫苗的有效性已经降低，需要加强剂管理。作为专业的抗原呈递细胞，树突状细胞也可以激活免疫系统，特别是 T 细胞。这种能力使得树突状细胞已被开发为某些类型疾病的疫苗。在 SARS-CoV-2 感染中，T 细胞在消除病毒方面起着至关重要的作用，它们的存在可以长期检测到。因此，这种情况表明形成 T 细胞免疫对于预防和控制疾病的进程至关重要。可以通过利用树突状细胞来构建针对诱导强 T 细胞反应的疫苗。在本文中，我们讨论并说明了树突状细胞和 T 细胞在 SARS-CoV-2 感染发病机制中的作用，并总结了树突状细胞在 T 细胞免疫形成中的关键作用。我们安排了用于 SARS-CoV-2 疫苗的树突状细胞开发的基本概念。基于树突状细胞的 SARS-CoV-2 疫苗有可能成为一种有效的疫苗，可以解决现有问题。
