Karlsen Trine, Engstrøm Morten, Steinshamn Sigurd L
Faculty of Nursing and Health Sciences, Nord University, Bodo, Norway.
Cardiac Exercise Research Group, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
BMJ Open Sport Exerc Med. 2022 Sep 19;8(3):e001366. doi: 10.1136/bmjsem-2022-001366. eCollection 2022.
Report on long-term follow-up results in the apnoea hypopnea index (AHI) and self-reported daytime sleepiness in participants with moderate to severe obstructive sleep apnoea at 12 weeks after completion of a high-intensity exercise training or control intervention.
Twenty-six participants with obstructive sleep apnoea (body mass index (BMI) 37 (36-39) kg/m, age 52 (49-55) years, apnoea-hypopnoea index 40.5 (31.3-50.2) events/hour), randomised to either 12 weeks of supervised high-intensity interval training (HIIT) (4×4 min of treadmill running or walking at 90%-95% of maximal heart rate) or no intervention (control), underwent a sleep evaluation follow-up 24 weeks after intervention initiation. Respiratory measures during sleep were registered at baseline, 12 weeks (postintervention) and 24 weeks (long-term follow-up).
At the 24-week follow-up, there were no statistically significant differences between the groups in the AHI (HIIT 30.7 (17.2-44.1) and control 38.7 (22.8-54.5) events/hour), Epworth score (HIIT 7.0 (4.7-9.3) and control 5.5 (3.9-7.0)), mean oxygen saturation (HIIT 93.2 (92.5-93.9) and control 92.0 (91.1-92.8)) or oxygen desaturation events (HIIT 32.9 (20.4-45.4) and control 44.3 (27.3-61.3) n/hour). BMI remained unchanged from the baseline in both groups. In the HIIT group, only two participants reported having continued with HIIT at 24 weeks.
The effect of 12 weeks of supervised high-intensity exercise training on AHI and self-reported daytime sleepiness was lost at the 24-week follow-up.
报告高强度运动训练或对照干预完成12周后，中度至重度阻塞性睡眠呼吸暂停参与者的呼吸暂停低通气指数（AHI）和自我报告的日间嗜睡情况的长期随访结果。
26名阻塞性睡眠呼吸暂停参与者（体重指数（BMI）为37（36 - 39）kg/m²，年龄52（49 - 55）岁，呼吸暂停低通气指数为40.5（31.3 - 50.2）次/小时），随机分为12周的有监督高强度间歇训练（HIIT）组（在跑步机上以最大心率的90% - 95%进行4×4分钟跑步或步行）或无干预组（对照组），在干预开始24周后进行睡眠评估随访。在基线、12周（干预后）和24周（长期随访）记录睡眠期间的呼吸指标。
在24周随访时，两组在AHI（HIIT组为30.7（17.2 - 44.1）次/小时，对照组为38.7（22.8 - 54.5）次/小时）、爱泼沃斯评分（HIIT组为7.0（4.7 - 9.3），对照组为5.5（3.9 - 7.0））、平均血氧饱和度（HIIT组为93.2（92.5 - 93.9），对照组为92.0（91.1 - 92.8））或血氧饱和度下降事件（HIIT组为32.9（20.4 - 45.4）次/小时，对照组为44.3（27.3 - 61.3）次/小时）方面无统计学显著差异。两组的BMI与基线相比均无变化。在HIIT组中，只有两名参与者报告在24周时仍继续进行HIIT。
在24周随访时，12周的有监督高强度运动训练对AHI和自我报告的日间嗜睡的影响消失。
