Karlsen Trine, Nes Bjarne Martens, Tjønna Arnt Erik, Engstrøm Morten, Støylen Asbjørn, Steinshamn Sigurd
K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
BMJ Open Sport Exerc Med. 2017 Feb 8;2(1). doi: 10.1136/bmjsem-2016-000155. eCollection 2016.
Three hours per week of vigorous physical activity is found to be associated with reduced odds of sleep-disordered breathing.
To investigate whether 12 weeks of high-intensity interval training (HIIT) reduced the apnoea-hypopnea index (AHI) in obese subjects with moderate-to-severe obstructive sleep apnoea.
In a prospective randomised controlled exercise study, 30 (body mass index 37±6 kg/m, age 51±9 years) patients with sleep apnoea (AHI 41.5±25.3 events/hour) were randomised 1:1 to control or 12 weeks of supervised HIIT (4×4 min of treadmill running or walking at 90%-95% of maximal heart rate two times per week).
In the HIIT group, the AHI was reduced by 7.5±11.6 events/hour (within-group p<0.05), self-reported sleepiness (Epworth scale) improved from 10.0±3.6 to 7.3±3.7 (between-group p<0.05) and maximal oxygen uptake improved from 28.2±7.4 to 30.2±7.7 mL/kg/min (between-group p<0.05) from baseline to 12 weeks. The AHI, self-reported sleepiness and VOwere unchanged from baseline to 12 weeks in controls (baseline AHI 50.3±25.5 events/hour, Epworth score 5.9±4.3, maximal oxygen uptake 27.0±6.8 mL/kg/min). Body weight remained unchanged in both groups.
Twelve weeks of HIIT improved the AHI and self-reported daytime sleepiness in subjects with obese sleep apnoea without any change in the desaturation index and body weight.
每周三小时的剧烈体育活动被发现与睡眠呼吸障碍几率降低有关。
调查12周的高强度间歇训练（HIIT）是否能降低中重度阻塞性睡眠呼吸暂停肥胖受试者的呼吸暂停低通气指数（AHI）。
在一项前瞻性随机对照运动研究中，30名睡眠呼吸暂停患者（体重指数37±6kg/m²，年龄51±9岁，AHI为41.5±25.3次/小时）按1:1随机分为对照组或接受12周的监督HIIT（每周两次，在跑步机上以最大心率的90%-95%跑步或行走4×4分钟）。
在HIIT组中，AHI降低了7.5±11.6次/小时（组内p<0.05），自我报告的嗜睡程度（爱泼沃斯量表）从10.0±3.6改善到7.3±3.7（组间p<0.05），最大摄氧量从28.2±7.4提高到30.2±7.7mL/kg/min（组间p<0.05），从基线到12周。对照组从基线到12周，AHI、自我报告的嗜睡程度和最大摄氧量均无变化（基线AHI为50.3±25.5次/小时，爱泼沃斯评分5.9±4.3，最大摄氧量27.0±6.8mL/kg/min）。两组体重均未改变。
12周的HIIT改善了肥胖睡眠呼吸暂停受试者的AHI和自我报告的白天嗜睡程度，而未饱和指数和体重无任何变化。
