School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.
Faculty of Medicine and Health, Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia.
Adv Healthc Mater. 2022 Dec;11(23):e2201714. doi: 10.1002/adhm.202201714. Epub 2022 Oct 17.
Injectable hydrogels can support the body's innate healing capability by providing a temporary matrix for host cell ingrowth and neovascularization. The clinical adoption of current injectable systems remains low due to their cumbersome preparation requirements, device malfunction, product dislodgment during administration, and uncontrolled biological responses at the treatment site. To address these challenges, a fully synthetic and ready-to-use injectable biomaterial is engineered that forms an adhesive hydrogel that remains at the administration site regardless of defect anatomy. The product elicits a negligible local inflammatory response and fully resorbs into nontoxic components with minimal impact on internal organs. Preclinical animal studies confirm that the engineered hydrogel upregulates the regeneration of both soft and hard tissues by providing a temporary matrix to support host cell ingrowth and neovascularization. In a pilot clinical trial, the engineered hydrogel is successfully administered to a socket site post tooth extraction and forms adhesive hydrogel that stabilizes blood clot and supports soft and hard tissue regeneration. Accordingly, this injectable hydrogel exhibits high therapeutic potential and can be adopted to address multiple unmet needs in different clinical settings.
可注射水凝胶可以通过为宿主细胞浸润和新血管生成提供临时基质来支持身体的内在愈合能力。由于当前可注射系统的制备要求繁琐、器械故障、在给药过程中产品移位以及在治疗部位不可控的生物学反应，其临床应用仍然很低。为了解决这些挑战，设计了一种完全合成且可随时使用的可注射生物材料，该材料形成一种粘性水凝胶，无论缺损解剖结构如何，都可留在给药部位。该产品仅引起轻微的局部炎症反应，并完全吸收为无毒成分，对内部器官的影响最小。临床前动物研究证实，通过提供临时基质来支持宿主细胞浸润和新血管生成，工程化水凝胶可上调软组织和硬组织的再生。在一项试点临床试验中，该工程水凝胶成功地施用于拔牙后的牙槽窝部位，并形成粘性水凝胶，稳定血凝块并支持软组织和硬组织的再生。因此，这种可注射水凝胶具有很高的治疗潜力，可以用于解决不同临床环境中的多种未满足的需求。
