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通过电泳沉积生成的临床适用电极上纳米涂层的机械稳定性。

Mechanical Stability of Nano-Coatings on Clinically Applicable Electrodes, Generated by Electrophoretic Deposition.

机构信息

Institute of Technical Chemistry I, University of Duisburg-Essen and Center for NanoIntegration Duisburg-Essen (CENIDE), 45141, Essen, Germany.

Department of Neurosurgery, Hannover Medical School, 30625, Hannover, Germany.

出版信息

Adv Healthc Mater. 2022 Dec;11(23):e2102637. doi: 10.1002/adhm.202102637. Epub 2022 Oct 13.

DOI:10.1002/adhm.202102637
PMID:36148583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11468750/
Abstract

The mechanical stability of implant coatings is crucial for medical approval and transfer to clinical applications. Here, electrophoretic deposition (EPD) is a versatile coating technique, previously shown to cause significant post-surgery impedance reduction of brain stimulation platinum electrodes. However, the mechanical stability of the resulting coating has been rarely systematically investigated. In this work, pulsed-DC EPD of laser-generated platinum nanoparticles (PtNPs) on Pt-based, 3D neural electrodes is performed and the in vitro mechanical stability is examined using agarose gel, adhesive tape, and ultrasonication-based stress tests. EPD-generated coatings are highly stable inside simulated brain environments represented by agarose gel tests as well as after in vivo stimulation experiments. Electrochemical stability of the NP-modified surfaces is tested via cyclic voltammetry and that multiple scans may improve coating stability could be verified, indicated by higher signal stability following highly invasive adhesive tape stress tests. The brain sections post neural stimulation in rats are analyzed via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). Measurements reveal higher levels of Pt near the region stimulated with coated electrodes, in comparison to uncoated controls. Even though local concentrations in the vicinity of the implanted electrode are elevated, the total Pt mass found is below systemic toxicologically relevant concentrations.

摘要

植入物涂层的机械稳定性对于医疗批准和转化为临床应用至关重要。在这里，电泳沉积（EPD）是一种通用的涂层技术，先前已被证明可显著降低脑刺激铂金电极的术后阻抗。然而，涂层的机械稳定性很少被系统地研究。在这项工作中，通过脉冲直流 EPD 将激光产生的铂纳米粒子（PtNPs）沉积在基于 Pt 的 3D 神经电极上，并使用琼脂糖凝胶、胶带和基于超声的应力测试来检查体外机械稳定性。在模拟脑环境中的琼脂糖凝胶测试以及体内刺激实验后，EPD 生成的涂层具有高度的稳定性。通过循环伏安法测试 NP 修饰表面的电化学稳定性，并验证多次扫描可能提高涂层稳定性，这可以通过高度侵入性的胶带应力测试后的更高信号稳定性来证明。通过激光烧蚀电感耦合等离子体质谱法（LA-ICP-MS）分析大鼠神经刺激后的脑组织切片。测量结果显示，与未涂层对照相比，在经涂层电极刺激的区域附近，Pt 的水平更高。尽管植入电极附近的局部浓度升高，但发现的总 Pt 质量低于系统毒理学相关浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/6ec0cc282891/ADHM-11-2102637-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/179952f1ae08/ADHM-11-2102637-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/81861abf7231/ADHM-11-2102637-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/dfac6f24fcfd/ADHM-11-2102637-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/6ec0cc282891/ADHM-11-2102637-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/4bb69474f57f/ADHM-11-2102637-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/4ff3d802dd30/ADHM-11-2102637-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/e6809dde1b41/ADHM-11-2102637-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/de96a073d220/ADHM-11-2102637-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/4dd134e22882/ADHM-11-2102637-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/179952f1ae08/ADHM-11-2102637-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/81861abf7231/ADHM-11-2102637-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/dfac6f24fcfd/ADHM-11-2102637-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9bc9/11468750/6ec0cc282891/ADHM-11-2102637-g002.jpg

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