Department of Pathology, Karpaga Vinayaga Institute of Medical Sciences and Research Centre, Chinnakolambakkam, Chengalpattu District, Tamil Nadu, India.
Pathology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.
Niger J Clin Pract. 2022 Sep;25(9):1584-1592. doi: 10.4103/njcp.njcp_292_22.
Myxoid soft tissue tumors are rare and diagnostically challenging group of tumors with varied biological behavior ranging from benign, locally aggressive to distantly metastasizing malignant tumors.
The objectives of the study are to identify the relative frequency and distribution of myxoid soft tissue tumors among patients in a tertiary care hospital and to study the clinicopathological features of these tumors. This was a retrospective cross-sectional study conducted in the department of pathology of a tertiary care hospital from January 2008 to December 2013.
Clinical and pathological details of all the 80 myxoid soft tissue tumors reported during the study period were retrieved from the records of department of pathology. Corresponding Hematoxylin & Eosin (H & E) slides were reviewed, and Immunohistochemistry (IHC) was carried out for confirmation. The relationship among various prognostic variables was analyzed in case of myxoid sarcomas.
Myxoid soft tissue tumors accounted for 3.7% among the soft tissue tumors with a predominance of malignant myxoid sarcomas (71.25%) in contrast to the overall picture of sarcomas. Myxoid neurofibroma (34.78%) was the most common benign tumor, while myxofibrosarcoma (33.33%) was the frequent myxoid sarcoma. A statistically significant correlation was seen between tumor size and depth (P-value: 0.038) and also between presence of vascular invasion and histological grade (P-value: 0.012) of sarcomas.
Light microscopic morphology, supplemented by ancillary techniques like IHC, remains the cornerstone for diagnosis of myxoid soft tissue tumors.
黏液样软组织肿瘤是一组罕见且具有挑战性的肿瘤，其生物学行为多样，包括良性、局部侵袭性和远处转移性恶性肿瘤。
本研究的目的是确定黏液样软组织肿瘤在一家三级保健医院患者中的相对频率和分布，并研究这些肿瘤的临床病理特征。这是一项回顾性横断面研究，于 2008 年 1 月至 2013 年 12 月在一家三级保健医院的病理学系进行。
从病理学系的记录中检索了在研究期间报告的 80 例黏液样软组织肿瘤的临床和病理详细信息。回顾了相应的苏木精和伊红（H & E）切片，并进行了免疫组织化学（IHC）以确认。在黏液样肉瘤中分析了各种预后变量之间的关系。
黏液样软组织肿瘤在软组织肿瘤中占 3.7%，恶性黏液样肉瘤（71.25%）占优势，与肉瘤的整体情况形成对比。黏液样神经纤维瘤（34.78%）是最常见的良性肿瘤，而黏液纤维肉瘤（33.33%）是常见的黏液样肉瘤。肿瘤大小和深度之间存在统计学显著相关性（P 值：0.038），以及血管侵犯和组织学分级之间也存在统计学显著相关性（P 值：0.012）。
显微镜下形态学，辅以免疫组织化学等辅助技术，仍然是诊断黏液样软组织肿瘤的基石。
