Ahuja Sanjana, Modi Nisha, Varma Amit, Kapur Shivani, Malukani Kamal, Sahu Harshita Deep
Department of Pathology and Lab Medicine, Sri Aurobindo Medical College & Post Graduate Institute, Indore, India.
Sultan Qaboos Univ Med J. 2025 May 2;25(1):122-131. doi: 10.18295/2075-0528.1014. eCollection 2025.
Myxoid soft tissue tumours (MSTTs) represent a complex group of mesenchymal neoplasms characterised by the production of an extracellular myxoid matrix, which often poses diagnostic challenges. This study aimed to identify the relative frequency, distribution and morphological spectrum of MSTT as well as to illustrate commonly encountered diagnostic difficulties.
This retrospective study of the clinicopathological profiles of MSTT cases at Sri Aurobindo Medical College & Post Graduate Institute, Indore, India, was conducted from January 2020 to December 2023.
A total of 110 MSTT cases were included in this study. These cases accounted for 7.3% of the soft tissue tumours (STTs), with a predominance of benign MSTT (n = 67, 60.9%). The fibroblastic/myofibroblastic family of STT constituted the majority (33.6%). The upper limb (34%) was the most frequently involved anatomical site for benign MSTT, with the 20-40 age range being the most common (46.3%). Tumour sizes were predominantly below 5 cm (57%), with 84% located superficially. In malignant MSTT, the lower limb (49%) was largely affected, with the 40-60 age group being predominant (46.5%), and the most common tumour size range was 5-10 cm (46.5%). Myxoid schwannoma (13.4%) was the most prevalent benign entity, while myxofibrosarcoma (20.9%) was the most frequent malignancy. A statistically significant correlation was observed between histological grade and tumour size ( = 0.006) as well as between grade and tumour depth ( = 0.015).
This study presented a comprehensive array of clinical and morphological features of MSTT with variable clinical significance. It highlighted potential caveats to aid in accurate diagnosis for optimal treatment selection.
黏液样软组织肿瘤（MSTT）是一组复杂的间叶性肿瘤，其特征是产生细胞外黏液样基质，这常常给诊断带来挑战。本研究旨在确定MSTT的相对频率、分布和形态谱，并阐明常见的诊断困难。
对印度印多尔市圣奥罗宾多医学院及研究生学院2020年1月至2023年12月期间MSTT病例的临床病理资料进行回顾性研究。
本研究共纳入110例MSTT病例。这些病例占软组织肿瘤（STT）的7.3%，以良性MSTT为主（n = 67，60.9%）。STT的成纤维细胞/肌成纤维细胞家族占大多数（33.6%）。上肢（34%）是良性MSTT最常累及的解剖部位，20 - 40岁年龄范围最为常见（46.3%）。肿瘤大小多在5 cm以下（57%），84%位于浅表。在恶性MSTT中，下肢受累较多（49%），40 - 60岁年龄组为主（46.5%），最常见的肿瘤大小范围是5 - 10 cm（46.5%）。黏液样神经鞘瘤（13.4%）是最常见的良性实体，而黏液纤维肉瘤（20.9%）是最常见的恶性肿瘤。观察到组织学分级与肿瘤大小之间（= 0.006）以及分级与肿瘤深度之间（= 0.015）存在统计学显著相关性。
本研究展示了MSTT一系列具有不同临床意义的临床和形态学特征。它强调了有助于准确诊断以选择最佳治疗方案的潜在注意事项。
