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对于在卵胞浆内单精子注射(ICSI)周期中接受控制性卵巢过度刺激的女性,宫腔镜息肉切除术是否需要取消周期?

Does hysteroscopic resection of polyps require cycle cancellation in women undergoing controlled ovarian hyperstimulation in the ICSI cycle?

作者信息

Oral Serkan

机构信息

Haliç University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey.

出版信息

Turk J Obstet Gynecol. 2022 Sep 23;19(3):201-206. doi: 10.4274/tjod.galenos.2022.79363.

DOI:10.4274/tjod.galenos.2022.79363
PMID:36149248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9511934/
Abstract

OBJECTIVE

Endometrial polyps are one of the most extensive pathologies in the uterus and can be detected incidentally during assisted reproductive therapy in asymptomatic women.

MATERIALS AND METHODS

In patients planned for in vitro fertilization or intracytoplasmic sperm injection (ICSI) treatment, embryo freezing, or cycle cancelation options are mandatory in many clinics when detected at the beginning of the cycle. In our study, in ICSI treatment, patients with a single endometrial polyp smaller than 1.5 cm, who underwent hysteroscopic polyp resection at the beginning of the cycle and underwent fresh embryo transfer without canceling the treatment (n=31), and patients with the same characteristics of endometrial polyp who underwent hysteroscopic polyp resection before the cycle (n=34) are compared within the pregnancy, abortion and live birth rates.

RESULTS

As a result, no statistical difference was found between the two groups' pregnancy, abortion, and live birth rates.

CONCLUSION

Hysteroscopic resection of polyps during ovarian stimulation in ICSI treatment does not affect pregnancy and live birth rates and may eliminate the necessity of freezing.

摘要

目的

子宫内膜息肉是子宫内最常见的病变之一,在无症状女性的辅助生殖治疗过程中可能会偶然被发现。

材料与方法

在计划进行体外受精或卵胞浆内单精子注射(ICSI)治疗、胚胎冷冻或周期取消的患者中,许多诊所规定,若在周期开始时检测到息肉,则这些选项是必须的。在我们的研究中,在ICSI治疗中,比较了在周期开始时接受宫腔镜息肉切除术且未取消治疗而进行新鲜胚胎移植的单个子宫内膜息肉小于1.5 cm的患者(n = 31),以及在周期前接受宫腔镜息肉切除术的具有相同子宫内膜息肉特征的患者(n = 34)的妊娠、流产和活产率。

结果

结果显示,两组的妊娠、流产和活产率之间未发现统计学差异。

结论

在ICSI治疗中,在卵巢刺激期间进行宫腔镜息肉切除术不会影响妊娠和活产率,并且可能消除冷冻的必要性。

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1
Does hysteroscopic resection of polyps require cycle cancellation in women undergoing controlled ovarian hyperstimulation in the ICSI cycle?对于在卵胞浆内单精子注射(ICSI)周期中接受控制性卵巢过度刺激的女性,宫腔镜息肉切除术是否需要取消周期?
Turk J Obstet Gynecol. 2022 Sep 23;19(3):201-206. doi: 10.4274/tjod.galenos.2022.79363.
2
Hysteroscopic polypectomy without cycle cancellation in IVF/ICSI cycles: a cross-sectional study.体外受精/卵胞浆内单精子注射周期中不取消周期的宫腔镜下息肉切除术:一项横断面研究
Eur J Obstet Gynecol Reprod Biol. 2016 Oct;205:37-42. doi: 10.1016/j.ejogrb.2016.08.019. Epub 2016 Aug 10.
3
Management of endometrial polyps diagnosed before or during ICSI cycles.经 ICSI 周期前或周期中诊断的子宫内膜息肉的处理。
Reprod Biomed Online. 2012 Jan;24(1):123-8. doi: 10.1016/j.rbmo.2011.09.002. Epub 2011 Sep 16.
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Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities.宫腔镜检查用于治疗与疑似子宫腔主要异常相关的不孕症。
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Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342).首次体外受精/卵胞浆内单精子注射周期后着床失败女性的子宫内膜搔刮术;能否提高活产率?SCRaTCH研究:一项随机对照试验(荷兰国家试验注册编号5342)
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Septate, subseptate and arcuate uterus decrease pregnancy and live birth rates in IVF/ICSI.纵隔、双角及弓形子宫会降低 IVF/ICSI 妊娠率和活产率。
Reprod Biomed Online. 2010 Nov;21(5):700-5. doi: 10.1016/j.rbmo.2010.06.028. Epub 2010 Jun 25.

本文引用的文献

1
Assessing couples' preferences for fresh or frozen embryo transfer: a discrete choice experiment.评估夫妇对新鲜或冷冻胚胎移植的偏好:一项离散选择实验。
Hum Reprod. 2021 Oct 18;36(11):2891-2903. doi: 10.1093/humrep/deab207.
2
Are There Any Predictors of Endometrial Premalignancy/Malignancy within Endometrial Polyps in Infertile Patients?不孕患者的子宫内膜息肉中是否存在子宫内膜癌前病变/恶性肿瘤的预测因素?
Gynecol Obstet Invest. 2019;84(5):512-518. doi: 10.1159/000501682. Epub 2019 Jul 16.
3
Endometrial polyps: Pathogenesis, sequelae and treatment.子宫内膜息肉:发病机制、后遗症及治疗
SAGE Open Med. 2019 May 2;7:2050312119848247. doi: 10.1177/2050312119848247. eCollection 2019.
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Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities.宫腔镜检查用于治疗与疑似子宫腔主要异常相关的不孕症。
Cochrane Database Syst Rev. 2018 Dec 5;12(12):CD009461. doi: 10.1002/14651858.CD009461.pub4.
5
Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes.新鲜胚胎与选择性冻融胚胎移植在体外受精/卵胞浆内单精子注射周期中的比较:生殖结局的系统评价和荟萃分析。
Hum Reprod Update. 2019 Jan 1;25(1):2-14. doi: 10.1093/humupd/dmy033.
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Three-dimensional saline infusion sonography compared to two-dimensional saline infusion sonography for the diagnosis of focal intracavitary lesions.三维盐水灌注超声与二维盐水灌注超声在诊断腔内局灶性病变中的比较。
Cochrane Database Syst Rev. 2017 May 5;5(5):CD011126. doi: 10.1002/14651858.CD011126.pub2.
7
Fresh versus frozen embryo transfers in assisted reproduction.辅助生殖中新鲜胚胎移植与冷冻胚胎移植的比较。
Cochrane Database Syst Rev. 2017 Mar 28;3(3):CD011184. doi: 10.1002/14651858.CD011184.pub2.
8
Endometrial Polyps and Subfertility.子宫内膜息肉与生育力低下
J Obstet Gynaecol India. 2017 Feb;67(1):9-14. doi: 10.1007/s13224-016-0929-4. Epub 2016 Aug 20.
9
Research and clinical management for women with abnormal uterine bleeding in the reproductive years: More than PALM-COEIN.育龄期异常子宫出血女性的研究与临床管理:不止于PALM-COEIN。
BJOG. 2017 Jan;124(2):185-189. doi: 10.1111/1471-0528.14431.
10
Systemic hypertension and diabetes mellitus as predictors of malignancy among women with endometrial polyps: a meta-analysis of observational studies.系统性高血压和糖尿病作为子宫内膜息肉女性患者恶性肿瘤预测因素的观察性研究的荟萃分析
Menopause. 2016 Jun;23(6):691-7. doi: 10.1097/GME.0000000000000602.