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Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti-tumourigenic effects: A model for human ketotherapy trials.

作者信息

Allenspach Karin, Borcherding Dana C, Iennarella-Servantez Chelsea A, Mosichuk Allison P, Atherly Todd, Sahoo Dipak Kumar, Kathrani Aarti, Suchodolski Jan S, Bourgois-Mochel Agnes, Serao Mariana Rossoni, Serao Nick V, Willette Auriel, Perez Beatriz Agulla, Gabriel Vojtech, Mao Sichao, Kilburn Logan, Dang Viet, Borts David, Almada Luciana L, Fernandez-Zapico Martin E, Phillips Gregory J, Jergens Albert E, Mochel Jonathan P

机构信息

Departments, of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA.

Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, Iowa, USA.

出版信息

Clin Transl Med. 2022 Sep;12(9):e1047. doi: 10.1002/ctm2.1047.

DOI:10.1002/ctm2.1047
PMID:36149786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9506423/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/83e27107f1af/CTM2-12-e1047-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/67652991abde/CTM2-12-e1047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/8b323b4bc63f/CTM2-12-e1047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/b7b35a41fb65/CTM2-12-e1047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/2a49c801fc2f/CTM2-12-e1047-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/83e27107f1af/CTM2-12-e1047-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/67652991abde/CTM2-12-e1047-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/8b323b4bc63f/CTM2-12-e1047-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/b7b35a41fb65/CTM2-12-e1047-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/2a49c801fc2f/CTM2-12-e1047-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bcc/9506423/83e27107f1af/CTM2-12-e1047-g005.jpg

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本文引用的文献

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Prostaglandins Other Lipid Mediat. 2022 Jun;160:106637. doi: 10.1016/j.prostaglandins.2022.106637. Epub 2022 Mar 24.
2
Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.转移性去势抵抗性前列腺癌中循环脂质与细胞因子的关系
Cancers (Basel). 2021 Oct 1;13(19):4964. doi: 10.3390/cancers13194964.
3
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species.
高脂肪饮食可增强翻译犬类肠道类器官模型中的细胞增殖并损害肠道通透性。
BMC Mol Cell Biol. 2024 Apr 30;25(1):14. doi: 10.1186/s12860-024-00512-w.
犬类和人类的转录组谱分析揭示了两种物种共有的癌症特异性基因模块和生物学机制。
PLoS Comput Biol. 2021 Sep 27;17(9):e1009450. doi: 10.1371/journal.pcbi.1009450. eCollection 2021 Sep.
4
The Ketogenic Diet Revisited: Beyond Ketones.重新审视生酮饮食:超越酮体
Front Neurol. 2021 Jul 30;12:720073. doi: 10.3389/fneur.2021.720073. eCollection 2021.
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Amino acid metabolism as a therapeutic target in cancer: a review.氨基酸代谢作为癌症治疗靶点的综述
Amino Acids. 2021 Aug;53(8):1169-1179. doi: 10.1007/s00726-021-03052-1. Epub 2021 Jul 22.
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LGR5/R-Spo1/Wnt3a axis promotes stemness and aggressive phenotype in hepatoblast-like hepatocellular carcinoma cell lines.LGR5/R-Spo1/Wnt3a 轴促进肝母细胞样肝癌细胞系的干性和侵袭表型。
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