Mallouh A A, Sa'di A R
Pediatr Infect Dis J. 1987 Jun;6(6):527-9. doi: 10.1097/00006454-198706000-00007.
Leukopenia and/or neutropenia are thought to be characteristic findings in patients with typhoid fever. In a study of 29 children 8 months to 15 years of age mild neutropenia was found in 1 (3%) and leukopenia in 6 (20%) patients. These findings are similar to those reported recently. Epinephrine stimulation tests done in 3 patients excluded the possibility of excessive margination as a cause of neutropenia or leukopenia. In 3 neutropenic or leukopenic patients bone marrow examination showed hemophagocytosis with an increased number of histiocytes that had phagocytized neutrophils, red blood cells and platelets. This phenomenon was not seen in the bone marrow of 3 patients with normal white blood cell counts. Hemophagocytosis is an important mechanism in producing neutropenia, anemia and thrombocytopenia in several infectious and noninfectious disorders.
白细胞减少和/或中性粒细胞减少被认为是伤寒患者的特征性表现。在一项针对29名8个月至15岁儿童的研究中，1名（3%）患者出现轻度中性粒细胞减少，6名（20%）患者出现白细胞减少。这些发现与最近报道的结果相似。对3名患者进行的肾上腺素刺激试验排除了粒细胞边缘池过度导致中性粒细胞减少或白细胞减少的可能性。在3名中性粒细胞减少或白细胞减少的患者中，骨髓检查显示存在噬血细胞现象，吞噬中性粒细胞、红细胞和血小板的组织细胞数量增加。在3名白细胞计数正常的患者骨髓中未见到这种现象。噬血细胞现象是几种感染性和非感染性疾病中导致中性粒细胞减少、贫血和血小板减少的重要机制。
