Anabire Nsoh Godwin, Aryee Paul Armah, Helegbe Gideon Kofi
Department of Biochemistry & Molecular Medicine, School of Medicine and Health Sciences, University for Development Studies, P. O. Box TL 1883, Tamale, Ghana.
Department of Nutritional Sciences, School of Allied Health Sciences, University for Development Studies, P. O. Box TL 1883, Tamale, Ghana.
BMC Res Notes. 2018 Jun 5;11(1):353. doi: 10.1186/s13104-018-3456-9.
Anemia, Leukopenia, and thrombocytopenia are commonly observed hematological abnormalities in malaria and typhoid patients. In this study, we evaluated the prevalence of cytopenias in patients with mono-infections of plasmodium parasites (malaria group) or salmonella bacteria (typhoid group). Full blood counts from 79 patients (age ranging from 18 to 77 years) categorized into malaria and typhoid groups at the Tamale Central Hospital were assessed.
Data generated were entered and analyzed using SPSS version 20 and Graphpad Prism 6. Values were observed to be significant at p < 0.05. The prevalence of cytopenias were; 29.6, 48.0% for anemia, 38.9, 12.0% for thrombocytopenia, 20.4, 12.0% for leukopenia, 13.0, 8.0% for bicytopenia and 5.6, 4.0% for pancytopenia in both malaria and typhoid groups respectively. Between the two groups of patients, thrombocytopenia was significantly associated with those in the malaria group (χ = 5.84, p < 0.016). No association was found between cytopenias and gender in patients in the malaria group; however, the middle aged group, 36-55 years, was significantly associated with anemia (χ = 12.97, p < 0.002). Cytopenias were not associated with gender, and with different age categories in patients in the typhoid group.
贫血、白细胞减少和血小板减少是疟疾和伤寒患者常见的血液学异常。在本研究中，我们评估了疟原虫单一感染患者（疟疾组）或沙门氏菌单一感染患者（伤寒组）血细胞减少的患病率。对塔马利中心医院79名年龄在18至77岁之间、分为疟疾组和伤寒组的患者进行了全血细胞计数评估。
使用SPSS 20版和Graphpad Prism 6对生成的数据进行录入和分析。观察到p < 0.05时数值具有显著性。血细胞减少的患病率分别为：疟疾组和伤寒组贫血患病率分别为29.6%、48.0%，血小板减少患病率分别为38.9%、12.0%，白细胞减少患病率分别为20.4%、12.0%，双血细胞减少患病率分别为13.0%、8.0%，全血细胞减少患病率分别为5.6%、4.0%。在两组患者中，血小板减少与疟疾组患者显著相关（χ = 5.84，p < 0.016）。在疟疾组患者中，血细胞减少与性别之间未发现关联；然而，36至55岁的中年组与贫血显著相关（χ = 12.97，p < 0.002）。在伤寒组患者中，血细胞减少与性别以及不同年龄类别均无关联。
