Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Unit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Nov;134(5):573-587. doi: 10.1016/j.oooo.2022.07.006. Epub 2022 Jul 21.
We performed a systematic review dedicated to pooling evidence for the associations of clinical features with malignant transformation (MT) and recurrence of 3 oral potentially malignant disorders (OPMDs) (actinic cheilitis [AC], oral leukoplakia [OL], and proliferative verrucous leukoplakia [PVL]).
We selected studies that included clinical features and risk factors (age, sex, site, size, appearance, alcohol intake, tobacco use, and sun exposure) of OL, PVL, and AC associated with recurrence and/or MT.
Based on the meta-analysis results, non-homogeneous OL appears to have a 4.53 times higher chance of recurrence after treatment. We also found 6.52 higher chances of MT of non-homogeneous OL. Another clinical feature related to higher MT chances is the location (floor of the mouth and tongue has 4.48 higher chances) and the size (OL with >200 mm in size has 4.10 higher chances of MT). Regarding habits, nonsmoking patients with OL have a 3.20 higher chance of MT. The only clinical feature related to higher chances of MT in patients with PVL was sex (females have a 2.50 higher chance of MT).
Our study showed that some clinical features may indicate greater chances of recurrence after treatment and MT of OPMD.
我们进行了一项系统评价，专门汇总了与 3 种口腔潜在恶性疾病（光化性唇炎[AC]、口腔白斑病[OL]和增殖性疣状白斑病[PVL]）的恶性转化（MT）和复发相关的临床特征的证据。
我们选择了包括 OL、PVL 和 AC 的临床特征和风险因素（年龄、性别、部位、大小、外观、酒精摄入、烟草使用和阳光暴露）与复发和/或 MT 相关的研究。
基于荟萃分析结果，非均质 OL 治疗后复发的可能性似乎高出 4.53 倍。我们还发现非均质 OL 的 MT 几率高出 6.52 倍。另一个与 MT 几率较高相关的临床特征是位置（口底和舌的 MT 几率高 4.48 倍）和大小（OL 大小>200mm 的 MT 几率高 4.10 倍）。关于习惯，OL 不吸烟患者的 MT 几率高出 3.20 倍。PVL 患者 MT 几率较高的唯一临床特征是性别（女性 MT 几率高 2.50 倍）。
我们的研究表明，一些临床特征可能表明 OPMD 治疗后复发和 MT 的几率更高。
