Paulsen O, Borgå O, Andersson K E
Pharmacol Toxicol. 1987 May;60(5):380-4. doi: 10.1111/j.1600-0773.1987.tb01531.x.
The effect of intravenously administered ampicillin on plasma levels and renal clearance of enprofylline was investigated in seven young and six elderly volunteers. On one occasion, each subject received 2 g of ampicillin intravenously, and serum concentrations of ampicillin were followed for 4 hours. On a separate occasion, a loading infusion of enprofylline was administered over 60 min., aiming at a plasma level of 2 micrograms/ml, and followed by a maintenance infusion. During this an infusion of 2 g of ampicillin was given for 10 min., and subsequently, renal clearance and plasma levels of enprofylline were followed for 4 hours. Plasma enprofylline levels increased significantly in the subjects after ampicillin infusion, but the effects on renal clearance of enprofylline were not statistically significant. The magnitude of the effects on enprofylline plasma levels and renal clearance from high doses of ampicillin do not suggest that interaction with beta-lactam antibiotics will be a serious problem for patients on enprofylline treatment.
在7名年轻志愿者和6名老年志愿者中研究了静脉注射氨苄西林对恩丙茶碱血浆水平和肾清除率的影响。在某一时刻，每位受试者静脉注射2g氨苄西林，并监测氨苄西林血清浓度4小时。在另一个时刻，在60分钟内给予恩丙茶碱负荷输注，目标血浆水平为2微克/毫升，随后进行维持输注。在此期间，给予2g氨苄西林输注10分钟，随后监测恩丙茶碱的肾清除率和血浆水平4小时。氨苄西林输注后受试者血浆恩丙茶碱水平显著升高，但对恩丙茶碱肾清除率的影响无统计学意义。高剂量氨苄西林对恩丙茶碱血浆水平和肾清除率的影响程度表明，与β-内酰胺类抗生素的相互作用对接受恩丙茶碱治疗的患者不会是一个严重问题。
