在有和没有阿莫西林或红霉素的情况下恩丙茶碱的处置情况。
Enprofylline disposition in the presence and absence of amoxycillin or erythromycin.
作者信息
Sitar D S, Aoki F Y, Hoban D J, Hidinger K G, Montgomery P R, Mitenko P A
出版信息
Br J Clin Pharmacol. 1987 Jul;24(1):57-61. doi: 10.1111/j.1365-2125.1987.tb03136.x.
1 The kinetic disposition of a novel xanthine bronchodilator, enprofylline, was determined in young healthy male volunteers in the presence and absence of amoxycillin or erythromycin. These data were compared to those derived from a similar study of theophylline disposition in the presence and absence of erythromycin. 2 Erythromycin inhibited theophylline disposition only in those subjects in whom the control kinetic study was done after antibiotic ingestion, but the effect was modest. Erythromycin had no effect on enprofylline disposition. 3 Amoxycillin reduced the renal clearance of enprofylline, but the change was not statistically significant.
在年轻健康男性志愿者中，测定了新型黄嘌呤支气管扩张剂恩丙茶碱在有或无阿莫西林或红霉素存在情况下的动力学处置情况。将这些数据与在有或无红霉素存在情况下进行的茶碱处置类似研究所得数据进行了比较。
红霉素仅在那些在抗生素摄入后进行对照动力学研究的受试者中抑制茶碱处置，但作用不大。红霉素对恩丙茶碱处置无影响。
阿莫西林降低了恩丙茶碱的肾清除率，但该变化无统计学意义。
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