Epling G A, Sibley M T
Photochem Photobiol. 1987 Jul;46(1):39-43. doi: 10.1111/j.1751-1097.1987.tb04733.x.
A family of 12 phototoxic quinolinemethanol antimalarials and three other non-phototoxic clinically used compounds were irradiated in the presence of red blood cells to determine if the resulting hemolysis would be a reliable predictor of phototoxicity. The most phototoxic compounds from in vivo tests were also the most phototoxic in this study. Quinine caused little RBC lysis, paralleling its non-phototoxicity in humans. The quinolinemethanol-induced photohemolysis occurs both in the presence and absence of oxygen. Enriching the RBC with BHA and cholesterol was particularly effective at protecting the cells from photohemolysis. Other compounds offered some measure of protection, while superoxide dismutase and sodium azide, among others, afforded no protection.
一个包含12种光毒性喹啉甲醇抗疟药的家族以及其他三种临床使用的非光毒性化合物在红细胞存在的情况下接受照射，以确定由此产生的溶血是否会成为光毒性的可靠预测指标。体内试验中光毒性最强的化合物在本研究中也是光毒性最强的。奎宁几乎不会引起红细胞溶解，这与其在人体中的非光毒性相一致。喹啉甲醇诱导的光溶血在有氧和无氧条件下都会发生。用丁基羟基茴香醚（BHA）和胆固醇富集红细胞对保护细胞免受光溶血特别有效。其他化合物提供了一定程度的保护，而超氧化物歧化酶和叠氮化钠等则没有提供保护。
