Gu Xin, Gao Chun-Qi
Guangdong Provincial Key Laboratory of Animal Nutrition Control/Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science, South China Agricultural University, Guangdong, China.
College of Animal Sciences, Zhejiang University, Hangzhou, China.
Anim Nutr. 2022 Jul 5;11:80-86. doi: 10.1016/j.aninu.2022.06.013. eCollection 2022 Dec.
Selenium (Se), one of the indispensable nutrients for both human health and animal growth, participates in various physiological functions, such as antioxidant and immune responses and metabolism. The role of dietary Se, in its organic and inorganic forms, has been well documented in domestic animals. Furthermore, many feeding strategies for different animals have been developed to increase the Se concentration in animal products to address Se deficiency and even as a potential nutritional strategy to treat free radical-associated diseases. Nevertheless, studies on investigating the optimum addition of Se in feed, the long-term consequences of Se usage in food for animal nutrition, the mechanism of metallic Se nanoparticle (SeNP) transformation in vivo, and the nutritional effects of SeNPs on feed workers and the environment are urgently needed. Starting from the absorption and metabolism mechanism of Se, this review discusses the antioxidant role of Se in detail. Based on this characteristic, we further investigated the application of Se in animal health and described some unresolved issues and unanswered questions warranting further investigation. This review is expected to provide a theoretical reference for improving the quality of food animal meat as well as for the development of Se-based biological nutrition enhancement technology.
硒（Se）是人类健康和动物生长不可或缺的营养素之一，参与多种生理功能，如抗氧化、免疫反应和新陈代谢。日粮中有机和无机形式的硒在家畜中的作用已有充分记载。此外，人们还开发了许多针对不同动物的饲养策略，以提高动物产品中的硒浓度，解决硒缺乏问题，甚至作为治疗自由基相关疾病的潜在营养策略。然而，迫切需要开展研究，以确定饲料中硒的最佳添加量、硒在动物营养食品中的长期使用后果、金属硒纳米颗粒（SeNP）在体内的转化机制，以及硒纳米颗粒对饲料工人和环境的营养影响。本文从硒的吸收和代谢机制入手，详细讨论了硒的抗氧化作用。基于这一特性，我们进一步研究了硒在动物健康中的应用，并描述了一些有待进一步研究的未解决问题。本综述有望为提高食用动物肉的质量以及硒基生物营养强化技术的发展提供理论参考。
