慢性肾脏病与认知障碍：肾-脑轴
Chronic Kidney Disease and Cognitive Impairment: The Kidney-Brain Axis.
作者信息
Xie Zuoquan, Tong Siyu, Chu Xingkun, Feng Teng, Geng Meiyu
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Green Valley (Shanghai) Pharmaceuticals Co. Ltd., Shanghai, China.
出版信息
Kidney Dis (Basel). 2022 May 3;8(4):275-285. doi: 10.1159/000524475. eCollection 2022 Jul.
BACKGROUND
Cognitive impairment, increasingly recognized as a major social burden, is commonly found in chronic kidney disease (CKD) patients.
SUMMARY
Vascular damage, uremic toxicity, oxidative stress, and peripheral/central inflammation induced by CKD might be involved in brain lesions and ultimately result in cognitive decline. Uncovering the pathophysiology of CKD-associated cognitive impairment is important for early diagnosis and prevention, which undoubtedly prompts innovative pharmacological treatments.
KEY MESSAGES
Here, we sequentially review the current understanding and advances in the epidemiology, risk factors, and pathological mechanisms of cognitive impairment in CKD. Furthermore, we summarize the currently available therapeutic strategies for cognitive impairment in CKD.
背景
认知障碍日益被视为一项重大社会负担，在慢性肾脏病（CKD）患者中普遍存在。
总结
CKD 引发的血管损伤、尿毒症毒性、氧化应激以及外周/中枢炎症可能与脑损伤有关，并最终导致认知能力下降。揭示 CKD 相关认知障碍的病理生理学对于早期诊断和预防至关重要，这无疑会推动创新药物治疗的发展。
关键信息
在此，我们依次回顾了目前对 CKD 患者认知障碍的流行病学、危险因素和病理机制的认识及进展。此外，我们总结了目前针对 CKD 患者认知障碍的可用治疗策略。
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