活化血小板——慢性肾脏病及心血管并发症的助推器

Gong Shuiqin, Wang Chenyu, Xiong Jiachuan, Zhao Jinghong, Yang Ke

Department of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Chongqing Clinical Research Center of Kidney and Urology Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Kidney Dis (Basel). 2022 Jun 3;8(4):297-307. doi: 10.1159/000525090. eCollection 2022 Jul.

Background Chronic kidney disease (CKD) has become a global public health problem nowadays. As cardiovascular diseases (CVDs) are the primary cause of death in advanced CKD patients, much attention has been paid to resolving their cardiovascular complications. However, managing CKD and cardiovascular complications is still a big challenge for nephrologists, as satisfactory treatments are still lacking. Platelets, the second most abundant cells in the blood, are the major participants of hemostasis, thrombosis, and wound healing. In recent years, platelets have been reported in various physiological and pathological processes, including CKD and CKD-related CVDs.

背景慢性肾脏病（CKD）如今已成为一个全球性的公共卫生问题。由于心血管疾病（CVDs）是晚期CKD患者的主要死因，因此人们已高度关注解决其心血管并发症。然而，对于肾脏病学家而言，管理CKD及其心血管并发症仍是一项巨大挑战，因为仍缺乏令人满意的治疗方法。血小板是血液中第二丰富的细胞，是止血、血栓形成和伤口愈合的主要参与者。近年来，血小板已被报道参与各种生理和病理过程，包括CKD及与CKD相关的CVDs。